2-(2,2-Difluorocyclopropyl)acetic acid

Base Information

Chemical Name:2-(2,2-Difluorocyclopropyl)acetic acid
CAS No.:123131-67-9
Molecular Formula:C5H6F2O2
Molecular Weight:136.098
Hs Code.:2916200090
DSSTox Substance ID:DTXSID70560585
Nikkaji Number:J1.307.391K
Mol file:123131-67-9.mol

Synonyms:2-(2,2-DIFLUOROCYCLOPROPYL)ACETIC ACID;123131-67-9;(2,2-DIFLUOROCYCLOPROPYL)ACETIC ACID;Cyclopropaneacetic acid, 2,2-difluoro-;MFCD19229279;2-(2,2-difluorocyclopropyl)-acetic acid;SCHEMBL8957598;DTXSID70560585;2,2-difluorocyclopropylacetic acid;2,2-difluorocyclopropyl-acetic acid;YEA13167;AKOS006376323;AB76278;AS-52981;SY260583;CS-0055996;2-(2,2-DIFLUOROCYCLOPROPYL)ACETICACID;2(c)\(2,2(c)\difluorocyclopropyl)acetic acid;EN300-658710;P15938;F2167-7620

Suppliers and Price of 2-(2,2-Difluorocyclopropyl)acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(2,2-Difluorocyclopropyl)aceticAcid
10mg
$ 45.00

Crysdot
2-(2,2-Difluorocyclopropyl)aceticacid 97%
5g
$ 1375.00

Crysdot
2-(2,2-Difluorocyclopropyl)aceticacid 97%
1g
$ 458.00

ChemBridge Corporation
(2,2-difluorocyclopropyl)aceticacid 95%
5 g
$ 1030.00

Activate Scientific
2-(2,2-Difluorocyclopropyl)acetic acid 97+%
5 g
$ 1254.00

Activate Scientific
2-(2,2-Difluorocyclopropyl)acetic acid 97+%
1 g
$ 443.00

Activate Scientific
2-(2,2-Difluorocyclopropyl)acetic acid 97+%
250 mg
$ 212.00

Total 9 raw suppliers

Chemical Property of 2-(2,2-Difluorocyclopropyl)acetic acid

Chemical Property:

PSA：37.30000
LogP:1.11630
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:136.03358575
Heavy Atom Count:9
Complexity:144

Purity/Quality:

99%, ^*data from raw suppliers

2-(2,2-Difluorocyclopropyl)aceticAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C1(F)F)CC(=O)O

Technology Process of 2-(2,2-Difluorocyclopropyl)acetic acid

There total 4 articles about 2-(2,2-Difluorocyclopropyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 117284-59-0
1,1-difluoro-2-(2'-hydroxy)ethyl-cyclopropane

: 123131-67-9
2-(2,2-difluorocyclopropyl)-acetic acid

Guidance literature:: With chromium(VI) oxide; sulfuric acid; In water; acetone; at 20 ℃; for 4h;
DOI:10.1021/ol005578s

Reference yield:

: 123131-71-5
Benzyl 2-(2,2-difluorocyclopropyl)acetate

: 123131-67-9
2-(2,2-difluorocyclopropyl)-acetic acid

Guidance literature:: With potassium hydroxide; In methanol;

Reference yield:

: 117388-09-7
2-(2,2-difluorocyclopropyl)ethyl benzoate

: 123131-67-9
2-(2,2-difluorocyclopropyl)-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.6 g / NaOH / H₂O / 3 h / Heating

2: 100 percent / CrO₃; H₂SO₄ / H₂O; acetone / 4 h / 20 °C

With chromium(VI) oxide; sodium hydroxide; sulfuric acid; In water; acetone; 1: saponification / 2: Oxidation;
DOI:10.1021/ol005578s