2‐(2,2‐difluorocyclopropyl)acetic acid

Base Information

• Chemical Name: 2‐(2,2‐difluorocyclopropyl)acetic acid
• CAS No.: 123131-67-9
• Molecular Formula: C5H6F2O2
• Molecular Weight: 136.098
• Hs Code.: 2916200090
• Mol file: 123131-67-9.mol

Synonyms:Cyclopropaneacetic acid,2,2-difluoro;2-(2,2-difluorocyclopropyl)-acetic acid;2',2'-difluorocyclopropyl acetic acid;

Chemical Property of 2‐(2,2‐difluorocyclopropyl)acetic acid

Chemical Property:

• PSA: 37.30000
• LogP: 1.11630

Purity/Quality:

99% ^*data from raw suppliers

2-(2,2-Difluorocyclopropyl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2‐(2,2‐difluorocyclopropyl)acetic acid

There total 4 articles about 2‐(2,2‐difluorocyclopropyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,1-difluoro-2-(2'-hydroxy)ethyl-cyclopropane (117284-59-0) → 2-(2,2-difluorocyclopropyl)-acetic acid (123131-67-9)

Guidance literature:

With chromium(VI) oxide; sulfuric acid; In water; acetone; at 20 ℃; for 4h;

DOI:10.1021/ol005578s

Reference yield:

Benzyl 2-(2,2-difluorocyclopropyl)acetate (123131-71-5) → 2-(2,2-difluorocyclopropyl)-acetic acid (123131-67-9)

Guidance literature:

With potassium hydroxide; In methanol;

Reference yield:

2-(2,2-difluorocyclopropyl)ethyl benzoate (117388-09-7) → 2-(2,2-difluorocyclopropyl)-acetic acid (123131-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.6 g / NaOH / H₂O / 3 h / Heating

2: 100 percent / CrO₃; H₂SO₄ / H₂O; acetone / 4 h / 20 °C

With chromium(VI) oxide; sodium hydroxide; sulfuric acid; In water; acetone; 1: saponification / 2: Oxidation;

DOI:10.1021/ol005578s

upstream raw materials:

1,1-difluoro-2-(2'-hydroxy)ethyl-cyclopropane

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

2-(2,2-difluorocyclopropyl)ethyl benzoate

Benzyl 2-(2,2-difluorocyclopropyl)acetate

Refernces

• 1、 -. "POLYCYCLIC TLR7/8 ANTAGONISTS AND USE THEREOF IN THE TREATMENT OF IMMUNE DISORDERS". Paragraph 00782. . Retrieved 2017/07/06.
• 2、 -. "2,2-difluorocyclopropylethane derivatives, processes for their preparation and their use as pesticides". . . Retrieved 2008/06/13.