(2R,4R)-4-((tert-butyldimethylsilyl)oxy)-1-(2-(4-methoxyphenethyl)-1,3-dithian-2-yl)pentadecan-2-ol

Base Information

Chemical Name:(2R,4R)-4-((tert-butyldimethylsilyl)oxy)-1-(2-(4-methoxyphenethyl)-1,3-dithian-2-yl)pentadecan-2-ol
CAS No.:1428636-18-3
Molecular Formula:C₃₄H₆₂O₃S₂Si
Molecular Weight:611.082
Hs Code.:

Synonyms:(2R,4R)-4-((tert-butyldimethylsilyl)oxy)-1-(2-(4-methoxyphenethyl)-1,3-dithian-2-yl)pentadecan-2-ol

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Chemical Property of (2R,4R)-4-((tert-butyldimethylsilyl)oxy)-1-(2-(4-methoxyphenethyl)-1,3-dithian-2-yl)pentadecan-2-ol

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Technology Process of (2R,4R)-4-((tert-butyldimethylsilyl)oxy)-1-(2-(4-methoxyphenethyl)-1,3-dithian-2-yl)pentadecan-2-ol

There total 7 articles about (2R,4R)-4-((tert-butyldimethylsilyl)oxy)-1-(2-(4-methoxyphenethyl)-1,3-dithian-2-yl)pentadecan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1428636-19-4
tert-butyldimethyl(((R)-1-((R)-oxiran-2-yl)tridecan-2-yl)oxy)silane

: 56438-60-9
2-[2-(4-methoxyphenyl)ethyl]-1,3-dithiane

: 1428636-18-3
(2R,4R)-4-((tert-butyldimethylsilyl)oxy)-1-(2-(4-methoxyphenethyl)-1,3-dithian-2-yl)pentadecan-2-ol

Guidance literature:: 2-[2-(4-methoxyphenyl)ethyl]-1,3-dithiane; With n-butyllithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

tert-butyldimethyl(((R)-1-((R)-oxiran-2-yl)tridecan-2-yl)oxy)silane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; for 0.5h; Inert atmosphere;
DOI:10.1016/j.tetasy.2013.02.005

Reference yield:

: (2R)-1-(oxiran-2-yl)tridecan-2-ol

: 1428636-18-3
(2R,4R)-4-((tert-butyldimethylsilyl)oxy)-1-(2-(4-methoxyphenethyl)-1,3-dithian-2-yl)pentadecan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / dichloromethane / 3 h / 20 °C

2.1: (S,S)-(salen)cobalt(III)(OAc) / tetrahydrofuran; water / 24 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran; hexane; N,N,N,N,N,N-hexamethylphosphoric triamide / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.5 h / Inert atmosphere

With 1H-imidazole; n-butyllithium; (S,S)-(salen)cobalt(III)(OAc); In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; water;
DOI:10.1016/j.tetasy.2013.02.005

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1428636-18-3
(2R,4R)-4-((tert-butyldimethylsilyl)oxy)-1-(2-(4-methoxyphenethyl)-1,3-dithian-2-yl)pentadecan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / dichloromethane / 3 h / 20 °C

2.1: (S,S)-(salen)cobalt(III)(OAc) / tetrahydrofuran; water / 24 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran; hexane; N,N,N,N,N,N-hexamethylphosphoric triamide / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.5 h / Inert atmosphere

With 1H-imidazole; n-butyllithium; (S,S)-(salen)cobalt(III)(OAc); In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; water;
DOI:10.1016/j.tetasy.2013.02.005