(S)-2-[3-(2-Amino-acetylamino)-2-oxo-4-phenyl-azetidin-1-yl]-4-methyl-pentanoic acid tert-butyl ester

Base Information

• Chemical Name: (S)-2-[3-(2-Amino-acetylamino)-2-oxo-4-phenyl-azetidin-1-yl]-4-methyl-pentanoic acid tert-butyl ester
• CAS No.: 79943-26-3
• Molecular Formula: C₂₁H₃₁N₃O₄
• Molecular Weight: 389.495
• Mol file: 79943-26-3.mol

Synonyms:(S)-2-[3-(2-Amino-acetylamino)-2-oxo-4-phenyl-azetidin-1-yl]-4-methyl-pentanoic acid tert-butyl ester

Chemical Property of (S)-2-[3-(2-Amino-acetylamino)-2-oxo-4-phenyl-azetidin-1-yl]-4-methyl-pentanoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[3-(2-Amino-acetylamino)-2-oxo-4-phenyl-azetidin-1-yl]-4-methyl-pentanoic acid tert-butyl ester

There total 6 articles about (S)-2-[3-(2-Amino-acetylamino)-2-oxo-4-phenyl-azetidin-1-yl]-4-methyl-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-2-[3-(2-Azido-acetylamino)-2-oxo-4-phenyl-azetidin-1-yl]-4-methyl-pentanoic acid tert-butyl ester → (S)-2-[3-(2-Amino-acetylamino)-2-oxo-4-phenyl-azetidin-1-yl]-4-methyl-pentanoic acid tert-butyl ester (79943-26-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; Ambient temperature;

DOI:10.1246/cl.1981.1297

Reference yield:

L-leucine tert-butyl ester (21691-53-2) → (S)-2-[3-(2-Amino-acetylamino)-2-oxo-4-phenyl-azetidin-1-yl]-4-methyl-pentanoic acid tert-butyl ester (79943-26-3)

Guidance literature:

Multi-step reaction with 5 steps

2: CH₂Cl₂

3: 100 percent / H₂ / Pd/C / methanol / Ambient temperature

4: 72 percent / N-methylmorpholine / CHCl₃

5: 100 percent / H₂ / Pd/C / methanol / Ambient temperature

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; chloroform;

DOI:10.1246/cl.1981.1297

Reference yield:

benzaldehyde (100-52-7) → (S)-2-[3-(2-Amino-acetylamino)-2-oxo-4-phenyl-azetidin-1-yl]-4-methyl-pentanoic acid tert-butyl ester (79943-26-3)

Guidance literature:

Multi-step reaction with 5 steps

2: CH₂Cl₂

3: 100 percent / H₂ / Pd/C / methanol / Ambient temperature

4: 72 percent / N-methylmorpholine / CHCl₃

5: 100 percent / H₂ / Pd/C / methanol / Ambient temperature

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; chloroform;

DOI:10.1246/cl.1981.1297

upstream raw materials:

L-leucine tert-butyl ester

benzaldehyde

N-benzylidene<(S)-1-t-butoxycarbonyl-3-methyl>butylamine

Downstream raw materials:

(D/L)-Tyr-Gly-Gly-(D/L)-Phe-(L)-Leu-OBu^t