2-chloro-N-methyl-5'-nitro-2'-[2-(1,2,3,4-tetrahydroisoquinolyl)]acetanilide

Base Information

• Chemical Name: 2-chloro-N-methyl-5'-nitro-2'-[2-(1,2,3,4-tetrahydroisoquinolyl)]acetanilide
• CAS No.: 449761-01-7
• Molecular Formula: C₁₈H₁₈ClN₃O₃
• Molecular Weight: 359.812
• Mol file: 449761-01-7.mol

Synonyms:2-chloro-N-methyl-5'-nitro-2'-[2-(1,2,3,4-tetrahydroisoquinolyl)]acetanilide

Chemical Property of 2-chloro-N-methyl-5'-nitro-2'-[2-(1,2,3,4-tetrahydroisoquinolyl)]acetanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-N-methyl-5'-nitro-2'-[2-(1,2,3,4-tetrahydroisoquinolyl)]acetanilide

There total 5 articles about 2-chloro-N-methyl-5'-nitro-2'-[2-(1,2,3,4-tetrahydroisoquinolyl)]acetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

chloroacetyl chloride (79-04-9) + N-methyl-5-nitro-2-[2-(1,2,3,4-tetrahydroisoquinolyl)]aniline (449760-94-5) → 2-chloro-N-methyl-5'-nitro-2'-[2-(1,2,3,4-tetrahydroisoquinolyl)]acetanilide (449761-01-7)

Guidance literature:

In acetone; at 20 ℃; for 0.25h;

DOI:10.1039/b109725c

Reference yield:

N-(2-fluoro-5-nitrophenyl)-4-methylbenzenesulfonamide → 2-chloro-N-methyl-5'-nitro-2'-[2-(1,2,3,4-tetrahydroisoquinolyl)]acetanilide (449761-01-7)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / acetone

2: hydrolysis

3: 99 percent / 110 - 120 °C

4: 86 percent / acetone / 0.25 h / 20 °C

With potassium carbonate; In acetone;

DOI:10.1039/b109725c

Reference yield:

1,2,3,4-tetrahydroisoquinoline (91-21-4) → 2-chloro-N-methyl-5'-nitro-2'-[2-(1,2,3,4-tetrahydroisoquinolyl)]acetanilide (449761-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / 110 - 120 °C

2: 86 percent / acetone / 0.25 h / 20 °C

In acetone;

DOI:10.1039/b109725c

upstream raw materials:

chloroacetyl chloride

N-methyl-5-nitro-2-[2-(1,2,3,4-tetrahydroisoquinolyl)]aniline

1,2,3,4-tetrahydroisoquinoline

2-fluoro-N-methyl-5-nitroaniline