3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxoproline

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Chemical Name:3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxoproline
CAS No.:1301660-82-1
Molecular Formula:C₃₀H₂₆F₇N₃O₄
Molecular Weight:625.543
Hs Code.:

Synonyms:3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxoproline

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Chemical Property of 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxoproline

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Technology Process of 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxoproline

There total 7 articles about 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxoproline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1301660-80-9
ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxoprolinate

: 1301660-82-1
3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxoproline

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 140 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 825643-73-0
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide

: 1301660-82-1
3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxoproline

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / Reflux

2.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 20 °C

2.2: 4 h / 20 °C

3.1: toluene / 2 h / Reflux

4.1: sodium ethanolate / ethanol; dimethyl sulfoxide / 0.5 h / 20 °C

4.2: 18 h / 110 °C

5.1: sodium hydroxide; water / methanol / 18 h / 20 °C

6.1: toluene; dimethyl sulfoxide / 3 h / 100 °C

7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.17 h / 140 °C / Microwave irradiation

With osmium(VIII) oxide; water; sodium ethanolate; sodium carbonate; sodium hydroxide; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 1301660-56-9
2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-formyl-3-pyridinyl]-N,2-dimethylpropanamide

: 1301660-82-1
3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxoproline

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 2 h / Reflux

2.1: sodium ethanolate / ethanol; dimethyl sulfoxide / 0.5 h / 20 °C

2.2: 18 h / 110 °C

3.1: sodium hydroxide; water / methanol / 18 h / 20 °C

4.1: toluene; dimethyl sulfoxide / 3 h / 100 °C

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.17 h / 140 °C / Microwave irradiation

With water; sodium ethanolate; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; toluene;