N-benzyloxycarbonyl-2-ethenylaniline

Base Information

• Chemical Name: N-benzyloxycarbonyl-2-ethenylaniline
• CAS No.: 894810-87-8
• Molecular Formula: C₁₆H₁₅NO₂
• Molecular Weight: 253.301
• Mol file: 894810-87-8.mol

Synonyms:N-benzyloxycarbonyl-2-ethenylaniline

Chemical Property of N-benzyloxycarbonyl-2-ethenylaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyloxycarbonyl-2-ethenylaniline

There total 4 articles about N-benzyloxycarbonyl-2-ethenylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-vinylaniline (3867-18-3) + benzyl chloroformate (501-53-1,94274-21-2) → N-benzyloxycarbonyl-2-ethenylaniline (894810-87-8)

Guidance literature:

With sodium carbonate; In dichloromethane; water; at 20 ℃; for 12h;

DOI:10.1021/jo060308u

Reference yield:

2-vinylbenzoic acid (27326-43-8) + benzyl alcohol (100-51-6,185532-71-2) → N-benzyloxycarbonyl-2-ethenylaniline (894810-87-8)

Guidance literature:

2-vinylbenzoic acid; With diphenyl-phosphinic acid; triethylamine; In benzene; at 20 ℃; for 1h;

benzyl alcohol; In benzene; Further stages.; Heating;

DOI:10.1016/j.tet.2003.08.079

Reference yield:

2-nitrostyrene (579-71-5) → N-benzyloxycarbonyl-2-ethenylaniline (894810-87-8)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; hydrogenchloride / ethanol / 78 °C

2: pyridine / ethyl acetate / 2 h / 20 °C

With pyridine; hydrogenchloride; iron; In ethanol; ethyl acetate;

DOI:10.1002/anie.201402661

upstream raw materials:

2-vinylbenzoic acid

benzyl alcohol

2-vinylaniline

benzyl chloroformate

Downstream raw materials:

allyl-(2-vinyl-phenyl)-carbamic acid benzyl ester

benzyl 3-(4-methyl-N-tosylphenylsulfonamido)-1H-indole-1-carboxylate

benzyl 6-methyl-1H-indole-1-carboxylate

1H-indole-1-carboxylic acid benzyl ester