2-(2-Bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Base Information

Chemical Name:2-(2-Bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
CAS No.:28180-48-5
Molecular Formula:C₉H₅BrF₆O
Molecular Weight:323.033
Hs Code.:
European Community (EC) Number:858-833-8
Nikkaji Number:J3.392.901C

Synonyms:28180-48-5;2-(2-Bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol;2-(2-Bromophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol;MFCD30188466;SY315364;EN300-22053178

Suppliers and Price of 2-(2-Bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-Bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:321.94280
Heavy Atom Count:17
Complexity:260

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C(C(F)(F)F)(C(F)(F)F)O)Br

Technology Process of 2-(2-Bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

There total 5 articles about 2-(2-Bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 80054-88-2
2,2,2‐trifluoroethyl 2‐bromobenzoate

: 28180-48-5
2‐(2‐bromophenyl)‐1,1,1,3,3,3‐hexafluoropropan‐2‐ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 18h; Inert atmosphere;
DOI:10.1002/anie.202104677

Reference yield:

: 7154-66-7
2-bromobenzoic acid chloride

: 28180-48-5
2‐(2‐bromophenyl)‐1,1,1,3,3,3‐hexafluoropropan‐2‐ol

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.202104677

Reference yield:

: 88-65-3
2-bromobenzoic-acid

: 28180-48-5
2‐(2‐bromophenyl)‐1,1,1,3,3,3‐hexafluoropropan‐2‐ol

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride; N,N-dimethyl-formamide / benzene / 3 h / Reflux; Inert atmosphere

2: pyridine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

With pyridine; thionyl chloride; tetrabutyl ammonium fluoride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1002/anie.202104677