1-(Imidazo[1,2-a]pyridin-3-yl)ethanone

Base Information

• Chemical Name: 1-(Imidazo[1,2-a]pyridin-3-yl)ethanone
• CAS No.: 29096-64-8
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.175
• Hs Code.: 2933990090
• European Community (EC) Number: 962-084-3
• DSSTox Substance ID: DTXSID30577331
• Wikidata: Q82467295
• Mol file: 29096-64-8.mol

Synonyms:1-(Imidazo[1,2-a]pyridin-3-yl)ethanone;29096-64-8;1-imidazo[1,2-a]pyridin-3-ylEthanone;Ethanone, 1-imidazo[1,2-a]pyridin-3-yl-;1-(Imidazo[1,2-a]pyridin-3-yl)ethan-1-one;Ethanone, 1-imidazo[1,2-a]pyridin-3-yl- (9CI);1-{Imidazo[1,2-a]pyridin-3-yl}ethan-1-one;1-Imidazo[1,2-a]pyridin-3-yl-ethanone;1-(H-imidazo[1,2-a]pyridin-3-yl)ethanone;SCHEMBL3549382;DTXSID30577331;GVIYJQYRNBCBJR-UHFFFAOYSA-N;Imidazo[1,2-a]pyridine-3-acetone;AKOS016006149;DS-4205;1-imidazo[1,2-a]pyridine-3-ylethanone;AM803644;CS-0084906;EN300-380853;W10345;A854635;J-503558;Z1255425112

Chemical Property of 1-(Imidazo[1,2-a]pyridin-3-yl)ethanone

Chemical Property:

• Melting Point: 98-99 °C
• PKA: 3.92±0.50(Predicted)
• PSA: 34.37000
• Density: 1.21 g/cm³
• LogP: 1.53690
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 160.063662883
• Heavy Atom Count: 12
• Complexity: 193

Purity/Quality:

97% ^*data from raw suppliers

1-(Imidazo[1,2-a]pyridin-3-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CN=C2N1C=CC=C2

Technology Process of 1-(Imidazo[1,2-a]pyridin-3-yl)ethanone

There total 9 articles about 1-(Imidazo[1,2-a]pyridin-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-aminopyridine (504-29-0) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + 1-bromoacetone (598-31-2) → 1-(imidazo[1,2-a]pyridin-3-yl)ethan-1-one (29096-64-8)

Guidance literature:

2-aminopyridine; N,N-dimethyl-formamide dimethyl acetal; for 23h; Reflux;

1-bromoacetone; In ethanol; at 20 ℃; for 24h;

DOI:10.1016/j.ejmech.2015.02.030

Reference yield: 64.0%

2-aminopyridine (504-29-0) + 2,2-dimethoxy-propane (77-76-9) + 1-bromoacetone (598-31-2) → 1-(imidazo[1,2-a]pyridin-3-yl)ethan-1-one (29096-64-8)

Guidance literature:

2-aminopyridine; 2,2-dimethoxy-propane; In N,N-dimethyl-formamide; for 23h; Reflux;

1-bromoacetone; In ethanol; N,N-dimethyl-formamide;

Reference yield: 45.0%

2-aminopyridine (504-29-0) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + chloroacetone (78-95-5) → 1-(imidazo[1,2-a]pyridin-3-yl)ethan-1-one (29096-64-8)

Guidance literature:

2-aminopyridine; N,N-dimethyl-formamide dimethyl acetal; Reflux;

chloroacetone; In ethanol; Reflux;

upstream raw materials:

water

imidazo[1,2-a]pyridine

acetic anhydride

2-(formylamino)pyridine

Downstream raw materials:

(E)-3-(dimethylamino)-1-(imidazo[1,2-a]pyridin-3-yl)prop-2-en-1-one

2-anilino-4-(imidazo[1,2-a]pyrid-3-yl)pyrimidine

C₂₅H₂₁N₇O

C₁₉H₁₅N₅O₂

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