2-(Formylamino)pyridine

Base Information

• Chemical Name: 2-(Formylamino)pyridine
• CAS No.: 34813-97-3
• Molecular Formula: C6H6N2O
• Molecular Weight: 122.126
• Hs Code.: 2933399090
• European Community (EC) Number: 836-023-5
• DSSTox Substance ID: DTXSID00396339
• Nikkaji Number: J660.522B
• Wikidata: Q72504694
• Mol file: 34813-97-3.mol

Synonyms:2-(Formylamino)pyridine;34813-97-3;N-(pyridin-2-yl)formamide;N-pyridin-2-ylformamide;N-(2-Pyridyl)formamide;formamidopyridine;N-(pyridine-2-yl)formamide;SCHEMBL80955;DTXSID00396339;NOCSAAHHSOQRCI-UHFFFAOYSA-N;AB9953;MFCD00043008;AKOS006223248;BS-28041;CS-0204324;FT-0701017;N-(2-Pyridyl)formamide, >=95.0% (HPLC);EN300-6759862

Chemical Property of 2-(Formylamino)pyridine

Chemical Property:

• Vapor Pressure: 0.000457mmHg at 25°C
• Melting Point: 69-71 °C
• Refractive Index: 1.602
• Boiling Point: 314.7 °C at 760 mmHg
• PKA: 13.69±0.70(Predicted)
• Flash Point: 144.1 °C
• PSA: 41.99000
• Density: 1.228 g/cm³
• LogP: 1.35880
• Solubility.: methanol: 0.1 g/mL, clear
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 122.048012819
• Heavy Atom Count: 9
• Complexity: 95.1

Purity/Quality:

99% ^*data from raw suppliers

2-(formylamino)pyridine 95 ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)NC=O

Technology Process of 2-(Formylamino)pyridine

There total 2 articles about 2-(Formylamino)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

formamide (77287-34-4,77287-35-5,60100-09-6) + chlorohydrate d'amino-2 pyridine (32654-45-8) → 2-(formylamino)pyridine (34813-97-3)

Guidance literature:

In toluene; at 120 ℃; for 3h; Green chemistry;

DOI:10.1002/ejoc.202101114

Reference yield: 6.0%

2-aminopyridine (504-29-0) + chloroform (67-66-3,8013-54-5) → 2-(formylamino)pyridine (34813-97-3) + 2-pyridinylisonitrile (1984-19-6)

Guidance literature:

With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; water; In dichloromethane; at 20 ℃;

Reference yield: 83.0%

2-(formylamino)pyridine (34813-97-3) + 4-Iodoacetophenone (13329-40-3) → 4-acetyl-N-(pyridin-2-yl)benzamide

Guidance literature:

With sodium hydrogencarbonate; dodecacarbonyl-triangulo-triruthenium; palladium dichloride; In acetonitrile; at 135 ℃; for 10h;

DOI:10.1021/ol034862r

upstream raw materials:

2-aminopyridine

chloroform

formamide

chlorohydrate d'amino-2 pyridine

Downstream raw materials:

N-ethyl-N-(2-pyridyl)formamide

2-(N-formyl-N-prop-2'-inyl)aminopyridin

N-(prop-2-yn-1-yl)pyridin-2-amine

N-methyl-N-(2-pyridyl)-formamide