4-Benzyloxy-3-hydroxyphenylacetic Acid

Base Information

• Chemical Name: 4-Benzyloxy-3-hydroxyphenylacetic Acid
• CAS No.: 28988-68-3
• Molecular Formula: C15H14 O4
• Molecular Weight: 258.274
• Hs Code.: 2918990090
• Mol file: 28988-68-3.mol

Synonyms:Aceticacid, [4-(benzyloxy)-3-hydroxyphenyl]- (8CI); 4-Benzyloxy-3-hydroxyphenylaceticacid

Chemical Property of 4-Benzyloxy-3-hydroxyphenylacetic Acid

Chemical Property:

• Melting Point: 108-110°C
• PSA: 66.76000
• LogP: 2.59830
• Solubility.: Chloroform, Methanol

Purity/Quality:

97% ^*data from raw suppliers

4-Benzyloxy-3-hydroxyphenylaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Benzyloxy-3-hydroxyphenylacetic Acid

There total 5 articles about 4-Benzyloxy-3-hydroxyphenylacetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

methyl 2-(4-(benzyloxy)-3-bromophenyl)acetate (101111-25-5) → 2-(4-(benzyloxy)-3-hydroxyphenyl)acetic acid (28988-68-3)

Guidance literature:

With water; copper; copper(II) oxide; potassium hydroxide; at 140 ℃; for 1h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.bmc.2012.12.016

Reference yield:

2-(4-(benzyloxy)-3-bromophenyl)acetic acid (5884-48-0) → 2-(4-(benzyloxy)-3-hydroxyphenyl)acetic acid (28988-68-3)

Guidance literature:

With 8-quinolinol; sodium hydroxide; In water; at 40 - 100 ℃; for 16h; Temperature; Inert atmosphere;

Reference yield:

Methyl 4-hydroxyphenylacetate (14199-15-6) → 2-(4-(benzyloxy)-3-hydroxyphenyl)acetic acid (28988-68-3)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; bromine / 2 h / 20 °C

2: potassium carbonate / acetone / Reflux

3: potassium hydroxide; water; copper; copper(II) oxide / 1 h / 140 °C / Inert atmosphere; Microwave irradiation

With water; bromine; copper; potassium carbonate; acetic acid; copper(II) oxide; potassium hydroxide; In acetone;

DOI:10.1016/j.bmc.2012.12.016

upstream raw materials:

Methyl 4-hydroxyphenylacetate

methyl 3-bromo-4-hydroxyphenylacetate

methyl 2-(4-(benzyloxy)-3-bromophenyl)acetate

2-(4-(benzyloxy)-3-bromophenyl)acetic acid

Downstream raw materials:

7-(benzyloxy)-8-hydroxy-1H-isochromen-3(4H)-one

(-)-corydalmine

C₂₀H₂₃NO₄

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