rac-2-amino-2-(3-nitrophenyl)propionic acid

Base Information

• Chemical Name: rac-2-amino-2-(3-nitrophenyl)propionic acid
• CAS No.: 1226060-08-7
• Molecular Formula: C₉H₁₀N₂O₄
• Molecular Weight: 210.189
• Mol file: 1226060-08-7.mol

Synonyms:rac-2-amino-2-(3-nitrophenyl)propionic acid

Chemical Property of rac-2-amino-2-(3-nitrophenyl)propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-2-amino-2-(3-nitrophenyl)propionic acid

There total 2 articles about rac-2-amino-2-(3-nitrophenyl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

rac-2-amino-2-(3-nitro-phenyl)-propionitrile (954272-07-2) → rac-2-amino-2-(3-nitrophenyl)propionic acid (1226060-08-7)

Guidance literature:

With hydrogenchloride; water; for 18h; Reflux;

DOI:10.1016/j.bmcl.2011.10.050

Reference yield:

3-Nitroacetophenone (121-89-1) → rac-2-amino-2-(3-nitrophenyl)propionic acid (1226060-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia; ammonium chloride / methanol / 96 h / 20 °C

2: hydrogenchloride; water / 18 h / Reflux

With hydrogenchloride; ammonia; water; ammonium chloride; In methanol; 1: Strecker reaction;

DOI:10.1016/j.bmcl.2011.10.050

Reference yield: 63.0%

methanol (67-56-1) + rac-2-amino-2-(3-nitrophenyl)propionic acid (1226060-08-7) → rac-2-amino-2-(3-nitro-phenyl)-propionic acid methyl ester (1350523-39-5)

Guidance literature:

methanol; rac-2-amino-2-(3-nitrophenyl)propionic acid; With thionyl chloride; at 0 ℃; for 0.25h;

for 18h; Reflux;

DOI:10.1016/j.bmcl.2011.10.050

upstream raw materials:

rac-2-amino-2-(3-nitro-phenyl)-propionitrile

3-Nitroacetophenone

Downstream raw materials:

rac-2-amino-2-(3-nitro-phenyl)-propionic acid methyl ester

C₁₉H₁₈F₃N₅O₂

rac-5-methylpyrazine-2-carboxylic acid [3-(6-amino-2,4-dimethyl-3-oxo-2,3,4,5-tetrahydropyrazin-2-yl)phenyl]amide

rac-2-amino-2-(3-nitro-phenyl)-propan-1-ol