(5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxymethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Base Information

Chemical Name:(5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxymethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester
CAS No.:87408-03-5
Molecular Formula:C₂₂H₃₀N₂O₇SSi
Molecular Weight:494.641
Hs Code.:

(5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxymethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Synonyms:(5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxymethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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Chemical Property of (5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxymethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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Technology Process of (5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxymethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

There total 8 articles about (5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxymethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94944-09-9
[3S-[3α(S*),4β]]-4-benzoyl-3-[1-[[[(1,1-dimethyl-ethyl)dimethyl]silyl]oxy]ethyl]-2-azetidinone

: 87408-03-5
(5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxymethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 89 percent / monoperphthalic acid / ethyl acetate / 18 h

2: 1) aq. EtOH, 0 deg C, 10 min; 2) 1 h

4: 58 percent / LiN(SiM₃)2 / tetrahydrofuran / 10 h / -78 °C

6: 1) m-CPBA; 2) NaHCO₃ / 1) CHCl₃, 10 min, 0 deg C; 2) H₂O

With monoperoxyphthalic acid; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/ja00291a069

Reference yield:

: 94944-10-2
(3R,4R)-4-benzoyloxy-3-<(1R)-(1-tert-butyldimethylsiloxy)ethyl>-azetidin-2-one

: 87408-03-5
(5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxymethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1) aq. EtOH, 0 deg C, 10 min; 2) 1 h

3: 58 percent / LiN(SiM₃)2 / tetrahydrofuran / 10 h / -78 °C

5: 1) m-CPBA; 2) NaHCO₃ / 1) CHCl₃, 10 min, 0 deg C; 2) H₂O

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/ja00291a069

Reference yield:

: (3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-((Z)-1-methylsulfanyl-2-nitro-vinylsulfanyl)-azetidin-2-one

: 87408-03-5
(5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxymethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

2: 58 percent / LiN(SiM₃)2 / tetrahydrofuran / 10 h / -78 °C

4: 1) m-CPBA; 2) NaHCO₃ / 1) CHCl₃, 10 min, 0 deg C; 2) H₂O

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/ja00291a069