(E)-1-(((3-iodo-2-methylallyl)oxy)methyl)-4-methoxybenzene

Base Information

Chemical Name:(E)-1-(((3-iodo-2-methylallyl)oxy)methyl)-4-methoxybenzene
CAS No.:446262-73-3
Molecular Formula:C₁₂H₁₅IO₂
Molecular Weight:318.154
Hs Code.:

Synonyms:(E)-1-(((3-iodo-2-methylallyl)oxy)methyl)-4-methoxybenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-1-(((3-iodo-2-methylallyl)oxy)methyl)-4-methoxybenzene

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Technology Process of (E)-1-(((3-iodo-2-methylallyl)oxy)methyl)-4-methoxybenzene

There total 3 articles about (E)-1-(((3-iodo-2-methylallyl)oxy)methyl)-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 4039-83-2
3-(4-methoxybenzyloxy)propyne

: 74-88-4
methyl iodide

: 446262-73-3
(E)-1-(((3-iodo-2-methylallyl)oxy)methyl)-4-methoxybenzene

Guidance literature:: 3-(4-methoxybenzyloxy)propyne; With n-butyllithium; tri-n-butyl-tin hydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; Petroleum ether; at -78 ℃; for 0.75h;

methyl iodide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; Petroleum ether; at 20 ℃; for 1h;

With iodine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; Petroleum ether; at 20 ℃; for 16h; Further stages.;
DOI:10.1021/jo0201777

Reference yield: 74.0%

: 70396-07-5,149694-62-2,70396-11-1
(E)-3-iodo-2-methyl-prop-2-en-1-ol

: 105-13-5
4-Methoxybenzyl alcohol

: 446262-73-3
(E)-1-(((3-iodo-2-methylallyl)oxy)methyl)-4-methoxybenzene

Guidance literature:: With O-(4-methoxybenzyl)-trichloroacetimidate; scandium tris(trifluoromethanesulfonate); In toluene; for 2h;
DOI:10.1021/acs.joc.9b01664

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 446262-73-3
(E)-1-(((3-iodo-2-methylallyl)oxy)methyl)-4-methoxybenzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

1.2: 85 percent / NaI / 18 h / Heating

2.1: CuCN; n-BuLi; n-Bu₃SnH / tetrahydrofuran; petroleum ether; hexamethylphosphoric acid triamide / 0.75 h / -78 °C

2.2: tetrahydrofuran; petroleum ether; hexamethylphosphoric acid triamide / 1 h / 20 °C

2.3: 88 percent / I₂ / tetrahydrofuran; petroleum ether; hexamethylphosphoric acid triamide / 16 h / 20 °C

With n-butyllithium; tri-n-butyl-tin hydride; sodium hydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; Petroleum ether;
DOI:10.1021/jo0201777