N-(1-cyclohexyl-3-oxo-3-phenylpropyl)-4-methyl benzenesulfonamide

Base Information

• Chemical Name: N-(1-cyclohexyl-3-oxo-3-phenylpropyl)-4-methyl benzenesulfonamide
• CAS No.: 1198790-83-8
• Molecular Formula: C₂₂H₂₇NO₃S
• Molecular Weight: 385.527
• Mol file: 1198790-83-8.mol

Synonyms:N-(1-cyclohexyl-3-oxo-3-phenylpropyl)-4-methyl benzenesulfonamide

Chemical Property of N-(1-cyclohexyl-3-oxo-3-phenylpropyl)-4-methyl benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-(1-cyclohexyl-3-oxo-3-phenylpropyl)-4-methyl benzenesulfonamide

There total 6 articles about N-(1-cyclohexyl-3-oxo-3-phenylpropyl)-4-methyl benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetophenone (98-86-2) + (E)-N-cyclohexylmethylene-4-toluenesulfonamide (260975-29-9) → N-(1-cyclohexyl-3-oxo-3-phenylpropyl)-4-methyl benzenesulfonamide (1198790-83-8)

Guidance literature:

With 1,2,2,6,6-pentamethylpiperidine; tris(pentafluorophenyl)borate; In hexane; toluene; at 22 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201608583

Reference yield: 82.0%

3-oxo-3-phenylpropionic acid (614-20-0) + N-(cyclohexylmethylene)-4-methylbenzenesulfonamide (175355-34-7) → N-(1-cyclohexyl-3-oxo-3-phenylpropyl)-4-methyl benzenesulfonamide (1198790-83-8)

Guidance literature:

In ethyl acetate; at 20 ℃; for 12h; Molecular sieve; Sealed tube;

DOI:10.1016/j.tetlet.2013.06.030

Reference yield: 79.0%

acetophenone (98-86-2) + N-(cyclohexylmethylene)-4-methylbenzenesulfonamide (175355-34-7) → N-(1-cyclohexyl-3-oxo-3-phenylpropyl)-4-methyl benzenesulfonamide (1198790-83-8)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 9h; Inert atmosphere;

DOI:10.1021/jo901982n

upstream raw materials:

acetophenone

N-(cyclohexylmethylene)-4-methylbenzenesulfonamide

toluene-4-sulfonamide

cyclohexanecarbaldehyde