(1S,5R,6R)-4-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-benzyl}-6-hydroxymethyl-3,8-diaza-bicyclo[3.2.1]octan-2-one

Base Information

Chemical Name:(1S,5R,6R)-4-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-benzyl}-6-hydroxymethyl-3,8-diaza-bicyclo[3.2.1]octan-2-one
CAS No.:115288-76-1
Molecular Formula:C₂₂H₃₆N₂O₃Si
Molecular Weight:404.625
Hs Code.:

Synonyms:(1S,5R,6R)-4-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-benzyl}-6-hydroxymethyl-3,8-diaza-bicyclo[3.2.1]octan-2-one

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Chemical Property of (1S,5R,6R)-4-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-benzyl}-6-hydroxymethyl-3,8-diaza-bicyclo[3.2.1]octan-2-one

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Technology Process of (1S,5R,6R)-4-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-benzyl}-6-hydroxymethyl-3,8-diaza-bicyclo[3.2.1]octan-2-one

There total 11 articles about (1S,5R,6R)-4-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-benzyl}-6-hydroxymethyl-3,8-diaza-bicyclo[3.2.1]octan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115288-75-0
(1S,5R,6R)-4-[1-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-phenyl}-meth-(Z)-ylidene]-6-hydroxymethyl-2-oxo-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid benzyl ester

: 115288-76-1
(1S,5R,6R)-4-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-benzyl}-6-hydroxymethyl-3,8-diaza-bicyclo[3.2.1]octan-2-one

Guidance literature:: With hydrogen; Ra-Ni (W₂); In ethanol; at 100 ℃; for 1.5h; under 103430 Torr;
DOI:10.1021/ja00223a052

Reference yield:

: 67373-56-2
chlorodimethyl(1,1,2-trimethylpropyl)silane

: 115288-76-1
(1S,5R,6R)-4-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-benzyl}-6-hydroxymethyl-3,8-diaza-bicyclo[3.2.1]octan-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: i-Pr₂NEt / 1,2-dichloro-ethane / 70 °C

2: t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / -78 °C

3: NH₃ / methanol / Ambient temperature

4: 82 percent / Et₃N, DMAP / CH₂Cl₂ / 24 h / -20 °C

5: NaBH₄ / methanol; CH₂Cl₂ / -20 °C

6: HgCl₂, CSA / acetonitrile; H₂O / 0.33 h / 40 °C

7: 59 percent / NaBH₄ / methanol; CH₂Cl₂ / 0 °C

8: H₂ / Ra-Ni (W₂) / ethanol / 1.5 h / 100 °C / 103430 Torr

With dmap; sodium tetrahydroborate; camphor-10-sulfonic acid; potassium tert-butylate; ammonia; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; mercury dichloride; Ra-Ni (W₂); In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ja00223a052

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 115288-76-1
(1S,5R,6R)-4-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-benzyl}-6-hydroxymethyl-3,8-diaza-bicyclo[3.2.1]octan-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: i-Pr₂NEt / 1,2-dichloro-ethane / 70 °C

2: t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / -78 °C

3: NH₃ / methanol / Ambient temperature

4: 82 percent / Et₃N, DMAP / CH₂Cl₂ / 24 h / -20 °C

5: NaBH₄ / methanol; CH₂Cl₂ / -20 °C

6: HgCl₂, CSA / acetonitrile; H₂O / 0.33 h / 40 °C

7: 59 percent / NaBH₄ / methanol; CH₂Cl₂ / 0 °C

8: H₂ / Ra-Ni (W₂) / ethanol / 1.5 h / 100 °C / 103430 Torr

With dmap; sodium tetrahydroborate; camphor-10-sulfonic acid; potassium tert-butylate; ammonia; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; mercury dichloride; Ra-Ni (W₂); In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ja00223a052