di-O-benzoyl-2,5-desoxy-3-trifluoroacetamido-3-β-D-ribofurannoside de methyle

Base Information

• Chemical Name: di-O-benzoyl-2,5-desoxy-3-trifluoroacetamido-3-β-D-ribofurannoside de methyle
• CAS No.: 78188-12-2
• Molecular Formula: C₂₂H₂₀F₃NO₇
• Molecular Weight: 467.399
• Mol file: 78188-12-2.mol

Synonyms:di-O-benzoyl-2,5-desoxy-3-trifluoroacetamido-3-β-D-ribofurannoside de methyle

Chemical Property of di-O-benzoyl-2,5-desoxy-3-trifluoroacetamido-3-β-D-ribofurannoside de methyle

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-O-benzoyl-2,5-desoxy-3-trifluoroacetamido-3-β-D-ribofurannoside de methyle

There total 3 articles about di-O-benzoyl-2,5-desoxy-3-trifluoroacetamido-3-β-D-ribofurannoside de methyle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

desoxy-3-O-isopropylidene-1,2-trifluoroacetamido-3-α-D-ribofurannose (29781-49-5) → di-O-benzoyl-2,5-desoxy-3-trifluoroacetamido-3-β-D-ribofurannoside de methyle (78188-12-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / pyridine / 14 h / 4 °C

2: 1.) HCl / 1.) MeOH, water, 8 h, 20 deg C, 2.) pyridine, 14 h, 4 deg C

With hydrogenchloride; In pyridine;

DOI:10.1002/hlca.19800630814

Reference yield:

3-O-isopropylidene-1,2-trifluoroacetamido-3-α-D-ribopentodialdofurannose (78188-23-5) → di-O-benzoyl-2,5-desoxy-3-trifluoroacetamido-3-β-D-ribofurannoside de methyle (78188-12-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / NaBH₄ / acetic acid / 2 h / 0 °C

2: 80 percent / pyridine / 14 h / 4 °C

3: 1.) HCl / 1.) MeOH, water, 8 h, 20 deg C, 2.) pyridine, 14 h, 4 deg C

With hydrogenchloride; sodium tetrahydroborate; In pyridine; acetic acid;

DOI:10.1002/hlca.19800630814

Reference yield:

methanol (67-56-1) + 3-(trifluoroacetamido)-1,2-O-isopropylidene-5-O-benzoyl-3-deoxy-α-D-ribofuranose (70894-62-1) + benzoyl chloride (98-88-4) → di-O-benzoyl-2,5-desoxy-3-trifluoroacetamido-3-β-D-ribofurannoside de methyle (78188-12-2)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction; 1.) MeOH, water, 8 h, 20 deg C, 2.) pyridine, 14 h, 4 deg C;

DOI:10.1002/hlca.19800630814

upstream raw materials:

methanol

3-(trifluoroacetamido)-1,2-O-isopropylidene-5-O-benzoyl-3-deoxy-α-D-ribofuranose

benzoyl chloride

3-O-isopropylidene-1,2-trifluoroacetamido-3-α-D-ribopentodialdofurannose