methyl 4-(benzyloxy)-3,5-difluorobenzoate

Base Information

• Chemical Name: methyl 4-(benzyloxy)-3,5-difluorobenzoate
• CAS No.: 1431533-45-7
• Molecular Formula: C₁₅H₁₂F₂O₃
• Molecular Weight: 278.255
• Mol file: 1431533-45-7.mol

Synonyms:methyl 4-(benzyloxy)-3,5-difluorobenzoate

Chemical Property of methyl 4-(benzyloxy)-3,5-difluorobenzoate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(benzyloxy)-3,5-difluorobenzoate

There total 6 articles about methyl 4-(benzyloxy)-3,5-difluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + 4-(benzyloxy)-3,5-difluorobenzaldehyde (125036-88-6) → methyl 4-(benzyloxy)-3,5-difluorobenzoate (1431533-45-7)

Guidance literature:

With iodine; potassium hydroxide; at 0 - 20 ℃; for 0.5h;

DOI:10.1002/cbic.201400033

Reference yield: 88.0%

methanol (67-56-1) + 4-(benzyloxy)-3,5-difluorobenzoic acid (1408143-67-8) → methyl 4-(benzyloxy)-3,5-difluorobenzoate (1431533-45-7)

Guidance literature:

With sulfuric acid; Reflux;

Reference yield:

3,5-difluoro-4-hydroxybenzaldehyde (118276-06-5) → methyl 4-(benzyloxy)-3,5-difluorobenzoate (1431533-45-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

2: potassium hydroxide; iodine / 0.5 h / 0 - 20 °C

With iodine; potassium carbonate; potassium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1002/cbic.201400033

upstream raw materials:

methanol

4-(benzyloxy)-3,5-difluorobenzaldehyde

3,5-difluoro-4-hydroxybenzaldehyde

benzyl bromide