ethyl 3-{4-[(3,4-dichlorobenzyl)oxy]-3-fluorophenyl}-3-hydroxypropanoate

Base Information

Chemical Name:ethyl 3-{4-[(3,4-dichlorobenzyl)oxy]-3-fluorophenyl}-3-hydroxypropanoate
CAS No.:1202577-52-3
Molecular Formula:C₁₈H₁₇Cl₂FO₄
Molecular Weight:387.235
Hs Code.:

Synonyms:ethyl 3-{4-[(3,4-dichlorobenzyl)oxy]-3-fluorophenyl}-3-hydroxypropanoate

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Chemical Property of ethyl 3-{4-[(3,4-dichlorobenzyl)oxy]-3-fluorophenyl}-3-hydroxypropanoate

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Technology Process of ethyl 3-{4-[(3,4-dichlorobenzyl)oxy]-3-fluorophenyl}-3-hydroxypropanoate

There total 3 articles about ethyl 3-{4-[(3,4-dichlorobenzyl)oxy]-3-fluorophenyl}-3-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1202577-51-2
4-[(3,4-dichlorobenzyl)oxy]-3-fluorobenzaldehyde

: 141-78-6
ethyl acetate

: 1202577-52-3
ethyl 3-{4-[(3,4-dichlorobenzyl)oxy]-3-fluorophenyl}-3-hydroxypropanoate

Guidance literature:: ethyl acetate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

4-[(3,4-dichlorobenzyl)oxy]-3-fluorobenzaldehyde; In tetrahydrofuran; at -78 ℃; for 0.5h;

Reference yield:

: 405-05-0
3-fluoro-4-hydroxybenzaldehyde

: 1202577-52-3
ethyl 3-{4-[(3,4-dichlorobenzyl)oxy]-3-fluorophenyl}-3-hydroxypropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C

With triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran;

Reference yield:

: 1805-32-9
3,4-dichlorobenzyl alcohol

: 1202577-52-3
ethyl 3-{4-[(3,4-dichlorobenzyl)oxy]-3-fluorophenyl}-3-hydroxypropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C

With triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran;