(S)-tert-butyl 2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carboxylate

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Chemical Name:(S)-tert-butyl 2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carboxylate
CAS No.:1610473-63-6
Molecular Formula:C₂₇H₃₀N₆O₄
Molecular Weight:502.573
Hs Code.:

Synonyms:(S)-tert-butyl 2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carboxylate

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Technology Process of (S)-tert-butyl 2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carboxylate

There total 4 articles about (S)-tert-butyl 2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610473-62-5
(S)-tert-butyl-2-((6-amino-8-oxo-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carboxylate

: 51067-38-0
4-phenoxyphenylboronic acid

: 1610473-63-6
(S)-tert-butyl 2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carboxylate

Guidance literature:: With pyridine; oxygen; copper diacetate; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1610473-59-0
(S)-tert-butyl 2-((6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)methyl)pyrrolidine-1-carboxylate

: 1610473-63-6
(S)-tert-butyl 2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; zinc / ethyl acetate; water / 2.5 h / 10 - 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 100 °C / Sealed tube; Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / acetic acid / 2.5 h / 90 °C / Autoclave; Inert atmosphere

4: pyridine; copper diacetate; oxygen / dichloromethane / 16 h / 20 °C

With pyridine; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; oxygen; copper diacetate; N-ethyl-N,N-diisopropylamine; zinc; In dichloromethane; water; acetic acid; ethyl acetate; 1,2-dichloro-ethane;

Reference yield:

: 1610473-61-4
(S)-tert-butyl 2-((6-(dibenzylamino)-8-oxo-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carboxylate

: 1610473-63-6
(S)-tert-butyl 2-((6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)methyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / acetic acid / 2.5 h / 90 °C / Autoclave; Inert atmosphere

2: pyridine; copper diacetate; oxygen / dichloromethane / 16 h / 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; oxygen; copper diacetate; In dichloromethane; acetic acid;