1-methyl-5'-O-(tert-butyldiphenylsilyl)-2',3'-O-(isopropylidene)pseudouridine

Base Information

• Chemical Name: 1-methyl-5'-O-(tert-butyldiphenylsilyl)-2',3'-O-(isopropylidene)pseudouridine
• CAS No.: 1024616-73-6
• Molecular Formula: C₂₉H₃₆N₂O₆Si
• Molecular Weight: 536.7
• Mol file: 1024616-73-6.mol

Synonyms:1-methyl-5'-O-(tert-butyldiphenylsilyl)-2',3'-O-(isopropylidene)pseudouridine

Chemical Property of 1-methyl-5'-O-(tert-butyldiphenylsilyl)-2',3'-O-(isopropylidene)pseudouridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-5'-O-(tert-butyldiphenylsilyl)-2',3'-O-(isopropylidene)pseudouridine

There total 1 articles about 1-methyl-5'-O-(tert-butyldiphenylsilyl)-2',3'-O-(isopropylidene)pseudouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5'-O-(tert-butyldiphenylsilyl)-2',3'-O-(isopropylidene)pseudouridine (1024616-70-3) + methyl iodide (74-88-4) → 1-methyl-5'-O-(tert-butyldiphenylsilyl)-2',3'-O-(isopropylidene)pseudouridine (1024616-73-6)

Guidance literature:

With N,O-bis-(trimethylsilyl)-acetamide; In dichloromethane; for 120h; Heating;

DOI:10.1016/j.bmc.2007.11.039

Reference yield: 94.0%

1-methyl-5'-O-(tert-butyldiphenylsilyl)-2',3'-O-(isopropylidene)pseudouridine (1024616-73-6) + methyl (S)-4-hydroxy-2-((tert-butoxy)carbonylamino)-butyrate (120042-11-7,258351-86-9) → 1-methyl-3-[(S)-3-N-(tert-butoxycarbonyl)amino-3-methoxycarbonylpropyl]-5'-O-(tert-butyldiphenylsilyl)-2',3'-O-(isopropylidene)pseudouridine (1024616-77-0)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2007.11.039

Reference yield: 90.0%

1-methyl-5'-O-(tert-butyldiphenylsilyl)-2',3'-O-(isopropylidene)pseudouridine (1024616-73-6) → N1-methylpseudouridine (13860-38-3)

Guidance literature:

With trifluoroacetic acid; In water; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2007.11.039

upstream raw materials:

5'-O-(tert-butyldiphenylsilyl)-2',3'-O-(isopropylidene)pseudouridine

methyl iodide

Downstream raw materials:

N¹-methylpseudouridine

1-methyl-3-[4-O-(tert-butyldimethylsilyl)butyl]-5'-O-(tert-butyldiphenylsilyl)-2',3'-O-(isopropylidene)pseudouridine

1-methyl-3-[(S)-3-N-(tert-butoxycarbonyl)amino-3-methoxycarbonylpropyl]-5'-O-(tert-butyldiphenylsilyl)-2',3'-O-(isopropylidene)pseudouridine