2-PHENYL-2,3-DIHYDRO-4-QUINOLONE

Base Information

• Chemical Name: 2-PHENYL-2,3-DIHYDRO-4-QUINOLONE
• CAS No.: 113567-29-6
• Molecular Formula: C15H13 N O
• Molecular Weight: 223.274
• Mol file: 113567-29-6.mol

Synonyms:4(1H)-Quinolinone,2,3-dihydro-2-phenyl-, (R)-

Chemical Property of 2-PHENYL-2,3-DIHYDRO-4-QUINOLONE

Chemical Property:

• Vapor Pressure: 6.2E-07mmHg at 25°C
• Refractive Index: 1.603
• Boiling Point: 410.1°Cat760mmHg
• PKA: 1.92±0.40(Predicted)
• Flash Point: 169°C
• PSA: 29.10000
• Density: 1.156g/cm³
• LogP: 3.56420

Purity/Quality:

98%min ^*data from raw suppliers

(R)-2-Phenyl-2,3-dihydroquinolin-4(1H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PHENYL-2,3-DIHYDRO-4-QUINOLONE

There total 15 articles about 2-PHENYL-2,3-DIHYDRO-4-QUINOLONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-phenyl-1H-quinolin-4-one (14802-18-7) → (R)-2-phenyl-2,3-dihydroquinolin-4(1H)-one (113567-29-6)

Guidance literature:

With (R,R)-(?)-2,3-bis(t-butylmethylphosphino)quinoxaline; triethylsilane; cobalt(II) aceylacetonate; In diethyl ether; at 20 ℃; for 12h; enantioselective reaction; Glovebox;

Reference yield: 82.0%

(2R)-benzyl 2-phenyl-4-oxo-3,4-dihydroquinoline-1(2H)-carboxylate (870694-48-7) → (R)-2-phenyl-2,3-dihydroquinolin-4(1H)-one (113567-29-6)

Guidance literature:

With potassium hydroxide; In methanol; for 1h; Heating;

DOI:10.1021/ol052257d

Reference yield: 72.0%

2-aminoacetophenone (551-93-9) + benzaldehyde (100-52-7) → (R)-2-phenyl-2,3-dihydroquinolin-4(1H)-one (113567-29-6)

Guidance literature:

With N-(pyrrolidin-2-ylmethyl)quinolin-8-amine; In neat (no solvent); at 25 ℃; for 36h; enantioselective reaction; Mechanism; Green chemistry;

DOI:10.1039/c6ra01247g

upstream raw materials:

2-Oxo-2-{N'-[(R)-2-phenyl-2,3-dihydro-1H-quinolin-(4E)-ylidene]-hydrazino}-N-(1-phenyl-ethyl)-acetamide

(2R)-benzyl 2-phenyl-4-oxo-3,4-dihydroquinoline-1(2H)-carboxylate

4(1H)-quinolinone

benzyl 4-oxoquinoline-1(4H)-carboxylate