Technology Process of 1-phenyl-2,3,4,.9-tetrahydro-β-carboline
There total 13 articles about 1-phenyl-2,3,4,.9-tetrahydro-β-carboline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
benzaldehyde; 5-methoxy-D-(+)-tryptophan ethyl ester;
With
sodium sulfate;
In
ethanol;
at 20 ℃;
Inert atmosphere;
With
sodium tetrahydroborate;
In
ethanol;
at 20 ℃;
DOI:10.1021/jo400469t
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrahydrofuran / 20 °C
2.1: tert.-butyl lithium; 1,2-Diiodoethane / diethyl ether / -78 °C
3.1: lithium chloride; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 36 h / 100 °C / Inert atmosphere
4.1: hydrogenchloride / tetrahydrofuran; water
5.1: sodium sulfate / ethanol / 20 °C / Inert atmosphere
5.2: 20 °C
With
hydrogenchloride; 1,2-Diiodoethane; tert.-butyl lithium; palladium diacetate; potassium carbonate; sodium sulfate; lithium chloride;
In
tetrahydrofuran; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo400469t
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / cyclohexane / Reflux
2.1: n-butyllithium / tetrahydrofuran / -78 °C
3.1: trimethylsilyl trifluoromethanesulfonate; 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C / Inert atmosphere
4.1: hydrogenchloride / tetrahydrofuran; water
5.1: sodium sulfate / ethanol / 20 °C / Inert atmosphere
5.2: 20 °C
With
2,6-dimethylpyridine; hydrogenchloride; N-Bromosuccinimide; n-butyllithium; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; sodium sulfate;
In
tetrahydrofuran; ethanol; dichloromethane; cyclohexane; water;
DOI:10.1021/jo400469t
