2-((2-bromoethyl)(2-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-4-nitrophenyl)amino)ethyl methanesulfonate

Base Information

• Chemical Name: 2-((2-bromoethyl)(2-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-4-nitrophenyl)amino)ethyl methanesulfonate
• CAS No.: 1563184-96-2
• Molecular Formula: C₂₂H₃₇BrN₃O₁₀PS
• Molecular Weight: 646.494
• Mol file: 1563184-96-2.mol

Synonyms:2-((2-bromoethyl)(2-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-4-nitrophenyl)amino)ethyl methanesulfonate

Chemical Property of 2-((2-bromoethyl)(2-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-4-nitrophenyl)amino)ethyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((2-bromoethyl)(2-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-4-nitrophenyl)amino)ethyl methanesulfonate

There total 7 articles about 2-((2-bromoethyl)(2-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-4-nitrophenyl)amino)ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

2-((2-bromoethyl)(2-((2-hydroxyethyl)carbamoyl)-4-nitrophenyl)amino)ethyl methanesulfonate (1563184-90-6) + di-tert-butyl diisopropylphosphoramide (137348-86-8) → 2-((2-bromoethyl)(2-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-4-nitrophenyl)amino)ethyl methanesulfonate (1563184-96-2)

Guidance literature:

2-((2-bromoethyl)(2-((2-hydroxyethyl)carbamoyl)-4-nitrophenyl)amino)ethyl methanesulfonate; di-tert-butyl diisopropylphosphoramide; With 1H-tetrazole; In N,N-dimethyl-formamide; acetonitrile; at 10 - 20 ℃;

With 3-chloro-benzenecarboperoxoic acid; In N,N-dimethyl-formamide; acetonitrile; at 5 - 20 ℃;

Reference yield:

2-fluoro-5-nitrobenzoic acid (7304-32-7) → 2-((2-bromoethyl)(2-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-4-nitrophenyl)amino)ethyl methanesulfonate (1563184-96-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 4 h / Reflux

1.2: 0.5 h / -10 - 20 °C

2.1: triethylamine / 1,4-dioxane / 55 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

4.1: methanesulfonyl chloride; methanol / 0.33 h / 20 °C

5.1: lithium bromide / acetone / 20 °C

6.1: 1H-tetrazole / acetonitrile; N,N-dimethyl-formamide / 10 - 20 °C

6.2: 5 - 20 °C

With 1H-tetrazole; methanol; thionyl chloride; methanesulfonyl chloride; triethylamine; N,N-dimethyl-formamide; lithium bromide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

2-(bis(2-hydroxyethyl)amino)-5-nitro-N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzamide (1563184-92-8) → 2-((2-bromoethyl)(2-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-4-nitrophenyl)amino)ethyl methanesulfonate (1563184-96-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

2.1: methanesulfonyl chloride; methanol / 0.33 h / 20 °C

3.1: lithium bromide / acetone / 20 °C

4.1: 1H-tetrazole / acetonitrile; N,N-dimethyl-formamide / 10 - 20 °C

4.2: 5 - 20 °C

With 1H-tetrazole; methanol; methanesulfonyl chloride; triethylamine; lithium bromide; In dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;

upstream raw materials:

2-((2-bromoethyl)(2-((2-hydroxyethyl)carbamoyl)-4-nitrophenyl)amino)ethyl methanesulfonate

di-tert-butyl diisopropylphosphoramide

2-fluoro-5-nitrobenzoic acid

2-fluoro-5-nitro-N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzamide

Downstream raw materials:

2-((2-bromoethyl)(4-nitro-2-((2-(phosphonooxy)ethyl)carbamoyl)phenyl)amino)ethyl methanesulfonate