2-fluoro-5-nitro-N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzamide

Base Information

• Chemical Name: 2-fluoro-5-nitro-N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzamide
• CAS No.: 1563184-91-7
• Molecular Formula: C₁₄H₁₇FN₂O₅
• Molecular Weight: 312.298
• Mol file: 1563184-91-7.mol

Synonyms:2-fluoro-5-nitro-N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzamide

Chemical Property of 2-fluoro-5-nitro-N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-fluoro-5-nitro-N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzamide

There total 3 articles about 2-fluoro-5-nitro-N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3,4-dihydro-2H-pyran (110-87-2) + 2-fluoro-N-(2-hydroxyethyl)-5-nitrobenzamide (1157576-21-0) → 2-fluoro-5-nitro-N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzamide (1563184-91-7)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃;

Reference yield: 41.0%

2-[(tetrahydropyran-2-yl)oxy]ethylamine (2201-20-9) + 2-fluoro-5-nitrobenzoic acid (7304-32-7) → 2-fluoro-5-nitro-N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzamide (1563184-91-7)

Guidance literature:

2-fluoro-5-nitrobenzoic acid; With thionyl chloride; N,N-dimethyl-formamide; for 4h; Reflux;

2-[(tetrahydropyran-2-yl)oxy]ethylamine; In tetrahydrofuran; at -10 - 20 ℃; for 0.5h;

Reference yield:

2-fluoro-5-nitrobenzoic acid (7304-32-7) → 2-fluoro-5-nitro-N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzamide (1563184-91-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 4 h / Reflux

1.2: 0.5 h / -10 - 20 °C

2.1: toluene-4-sulfonic acid / dichloromethane / 20 °C

With thionyl chloride; toluene-4-sulfonic acid; N,N-dimethyl-formamide; In dichloromethane;

upstream raw materials:

2-fluoro-5-nitrobenzoic acid

2-[(tetrahydropyran-2-yl)oxy]ethylamine

3,4-dihydro-2H-pyran

2-fluoro-N-(2-hydroxyethyl)-5-nitrobenzamide

Downstream raw materials:

((4-nitro-2-((2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)carbamoyl)phenyl)azanediyl)bis(ethane-2,1-diyl)dimethanesulfonate

((2-((2-hydroxyethyl)carbamoyl)-4-nitrophenyl)azanediyl)bis(ethane-2,1-diyl)dimethanesulfonate

2-((2-bromoethyl)(2-((2-hydroxyethyl)carbamoyl)-4-nitrophenyl)amino)ethyl methanesulfonate

2-((2-bromoethyl)(2-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-4-nitrophenyl)amino)ethyl methanesulfonate