(2α,3α,4α)-N,N-diethyl-1-hydroxy-2,4-dimethyl-3-phenyl-2-azetidinemethanamine

Base Information

Chemical Name:(2α,3α,4α)-N,N-diethyl-1-hydroxy-2,4-dimethyl-3-phenyl-2-azetidinemethanamine
CAS No.:83152-70-9
Molecular Formula:C₁₆H₂₆N₂O
Molecular Weight:262.395
Hs Code.:

Synonyms:(2α,3α,4α)-N,N-diethyl-1-hydroxy-2,4-dimethyl-3-phenyl-2-azetidinemethanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2α,3α,4α)-N,N-diethyl-1-hydroxy-2,4-dimethyl-3-phenyl-2-azetidinemethanamine

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Technology Process of (2α,3α,4α)-N,N-diethyl-1-hydroxy-2,4-dimethyl-3-phenyl-2-azetidinemethanamine

There total 4 articles about (2α,3α,4α)-N,N-diethyl-1-hydroxy-2,4-dimethyl-3-phenyl-2-azetidinemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 82238-35-5
(2α,3α,4α)-N,N-diethyl-1-hydroxy-2,4-dimethyl-3-phenyl-2-azetidinecarboxamide

: 83152-70-9
(2α,3α,4α)-N,N-diethyl-1-hydroxy-2,4-dimethyl-3-phenyl-2-azetidinemethanamine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 5h; Ambient temperature;
DOI:10.1002/recl.19881070205

Reference yield: 61.0%

: 75909-31-8
N,N-diethyl-2,3-dihydro-2,4-dimethyl-3-phenyl-2-azetecarboxamide 1-oxide

: 83152-70-9
(2α,3α,4α)-N,N-diethyl-1-hydroxy-2,4-dimethyl-3-phenyl-2-azetidinemethanamine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 5h;
DOI:10.1021/jo00144a006

Reference yield:

: 78602-07-0
(cis)-N,N-diethyl-2,3-dihydro-2-methyl-3-phenyl-2-azetecarboxamide 1-oxide

: 83152-70-9
(2α,3α,4α)-N,N-diethyl-1-hydroxy-2,4-dimethyl-3-phenyl-2-azetidinemethanamine

Guidance literature:: Multi-step reaction with 3 steps

1: 76.5 percent / benzene; diethyl ether / 0.3 h / Ambient temperature

2: 76 percent / yellow HgO / CH₂Cl₂ / 3 h / 25 °C

3: 61 percent / LiAlH₄ / tetrahydrofuran / 5 h / 0 °C

With lithium aluminium tetrahydride; mercury(II) oxide; In tetrahydrofuran; diethyl ether; dichloromethane; benzene;
DOI:10.1021/jo00144a006