3-(N-Boc-aminomethyl)-5-bromopyridine

Base Information

• Chemical Name: 3-(N-Boc-aminomethyl)-5-bromopyridine
• CAS No.: 943722-24-5
• Molecular Formula: C11H15 Br N2 O2
• Molecular Weight: 287.156
• Hs Code.: 2933399090
• Mol file: 943722-24-5.mol

Synonyms:tert-Butyl[(5-bromopyridin-3-yl)methyl]carbamate

Chemical Property of 3-(N-Boc-aminomethyl)-5-bromopyridine

Chemical Property:

• PSA: 51.22000
• LogP: 3.25970

Purity/Quality:

97% ^*data from raw suppliers

3-(BOC-Aminomethyl)-5-bromopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(N-Boc-aminomethyl)-5-bromopyridine

There total 7 articles about 3-(N-Boc-aminomethyl)-5-bromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(5-bromo-3-pyridinyl)methylamine (135124-70-8) + di-tert-butyl dicarbonate (24424-99-5) → 3-bromo-5-(tert-butoxycarbonyl)aminomethylpyridine (943722-24-5)

Guidance literature:

With triethylamine; In methanol; at 0 - 20 ℃; for 3h;

Reference yield:

5-bromo-pyridin-3-ylmethyl chloride (120277-69-2) + di-tert-butyl dicarbonate (24424-99-5) → 3-bromo-5-(tert-butoxycarbonyl)aminomethylpyridine (943722-24-5)

Guidance literature:

di-tert-butyl dicarbonate; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere; Alkaline conditions;

5-bromo-pyridin-3-ylmethyl chloride; In tetrahydrofuran; at 20 - 50 ℃; Inert atmosphere; Alkaline conditions;

DOI:10.1021/acs.jmedchem.9b01573

Reference yield:

iminodicarboxylic acid di-tert-butyl ester (51779-32-9) + 3-bromo-5-(chloromethyl)-pyridine hydrochloride (39741-46-3) → 3-bromo-5-(tert-butoxycarbonyl)aminomethylpyridine (943722-24-5)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

(5-bromo-3-pyridinyl)methylamine

di-tert-butyl dicarbonate

5-bromo-3-pyridine carboxylic acid methyl ester

(5-bromopyridin-3-yl)methanol