(1R,2R)-2-[benzyl(but-3-en-1-yl)amino]-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]but-3-en-1-ol

Base Information

Chemical Name:(1R,2R)-2-[benzyl(but-3-en-1-yl)amino]-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]but-3-en-1-ol
CAS No.:863029-49-6
Molecular Formula:C₂₀H₂₉NO₃
Molecular Weight:331.455
Hs Code.:

Synonyms:(1R,2R)-2-[benzyl(but-3-en-1-yl)amino]-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]but-3-en-1-ol

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Chemical Property of (1R,2R)-2-[benzyl(but-3-en-1-yl)amino]-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]but-3-en-1-ol

Chemical Property:

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Technology Process of (1R,2R)-2-[benzyl(but-3-en-1-yl)amino]-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]but-3-en-1-ol

There total 4 articles about (1R,2R)-2-[benzyl(but-3-en-1-yl)amino]-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]but-3-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 863029-48-5
(1R,2R)-2-(benzylamino)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]but-3-en-1-ol

: 80379-05-1
but-3-en-1-yl triflate

: 863029-49-6
(1R,2R)-2-[benzyl(but-3-en-1-yl)amino]-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]but-3-en-1-ol

Guidance literature:: With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In dichloromethane; at 20 ℃;
DOI:10.1039/b505303j

Reference yield:

: Benzyl-[1-[(2R,3S)-3-(tert-butyl-diphenyl-silanyloxymethyl)-oxiranyl]-meth-(E)-ylidene]-amine

: 863029-49-6
(1R,2R)-2-[benzyl(but-3-en-1-yl)amino]-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]but-3-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: Et₂OBF₃ / diethyl ether / -78 °C

2: 70 percent / aq. H₂SO₄ / dioxane / Heating

3: 80 percent / camphorsulfonic acid / 48 h / 20 °C

4: 72 percent / 1,8-bis(dimethylamino)naphthalene / CH₂Cl₂ / 20 °C

With sulfuric acid; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1039/b505303j

Reference yield:

: 357278-33-2
Benzyl-{(R)-1-[(2R,3S)-3-(tert-butyl-diphenyl-silanyloxymethyl)-oxiranyl]-allyl}-amine

: 863029-49-6
(1R,2R)-2-[benzyl(but-3-en-1-yl)amino]-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]but-3-en-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / aq. H₂SO₄ / dioxane / Heating

2: 80 percent / camphorsulfonic acid / 48 h / 20 °C

3: 72 percent / 1,8-bis(dimethylamino)naphthalene / CH₂Cl₂ / 20 °C

With sulfuric acid; camphor-10-sulfonic acid; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In 1,4-dioxane; dichloromethane;
DOI:10.1039/b505303j