4-[4-(4-chloro-phenyl)-2-(2-methyl-imidazol-1-yl)-oxazol-5-yl]-butyric acid ethyl ester

Base Information

Chemical Name:4-[4-(4-chloro-phenyl)-2-(2-methyl-imidazol-1-yl)-oxazol-5-yl]-butyric acid ethyl ester
CAS No.:198064-50-5
Molecular Formula:C₁₉H₂₀ClN₃O₃
Molecular Weight:373.839
Hs Code.:

Synonyms:4-[4-(4-chloro-phenyl)-2-(2-methyl-imidazol-1-yl)-oxazol-5-yl]-butyric acid ethyl ester

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Chemical Property of 4-[4-(4-chloro-phenyl)-2-(2-methyl-imidazol-1-yl)-oxazol-5-yl]-butyric acid ethyl ester

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Technology Process of 4-[4-(4-chloro-phenyl)-2-(2-methyl-imidazol-1-yl)-oxazol-5-yl]-butyric acid ethyl ester

There total 10 articles about 4-[4-(4-chloro-phenyl)-2-(2-methyl-imidazol-1-yl)-oxazol-5-yl]-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-03-6
ethyl iodide

: 198064-49-2
4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolebutanoic acid

: 198064-50-5
4-[4-(4-chloro-phenyl)-2-(2-methyl-imidazol-1-yl)-oxazol-5-yl]-butyric acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1248/cpb.51.565

Reference yield:

: 35444-44-1
methyl adipoyl chloride

: 198064-50-5
4-[4-(4-chloro-phenyl)-2-(2-methyl-imidazol-1-yl)-oxazol-5-yl]-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: AlCl₃ / 2 h / 20 °C

2: 31.7 g / Br₂ / CH₂Cl₂ / 20 °C

3: HCO₂Na / methanol / 12 h / Heating

4: 24.8 g / pyridine / tetrahydrofuran / 1 h / 20 °C

5: 69 percent / NH₄OAc; AcOH / Heating

6: 78 percent / POCl₃; pyridine / 125 °C

7: 76 percent / aq. NaOH / ethanol / 20 °C

8: K₂CO₃ / dimethylformamide / 120 - 130 °C

9: K₂CO₃ / dimethylformamide / 20 °C

With pyridine; sodium hydroxide; aluminium trichloride; ammonium acetate; bromine; sodium formate; potassium carbonate; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Friedel-Crafts reaction;
DOI:10.1248/cpb.51.565

Reference yield:

: 108-90-7
chlorobenzene

: 198064-50-5
4-[4-(4-chloro-phenyl)-2-(2-methyl-imidazol-1-yl)-oxazol-5-yl]-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: AlCl₃ / 2 h / 20 °C

2: 31.7 g / Br₂ / CH₂Cl₂ / 20 °C

3: HCO₂Na / methanol / 12 h / Heating

4: 24.8 g / pyridine / tetrahydrofuran / 1 h / 20 °C

5: 69 percent / NH₄OAc; AcOH / Heating

6: 78 percent / POCl₃; pyridine / 125 °C

7: 76 percent / aq. NaOH / ethanol / 20 °C

8: K₂CO₃ / dimethylformamide / 120 - 130 °C

9: K₂CO₃ / dimethylformamide / 20 °C

With pyridine; sodium hydroxide; aluminium trichloride; ammonium acetate; bromine; sodium formate; potassium carbonate; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Friedel-Crafts reaction;
DOI:10.1248/cpb.51.565