NEU-624

Base Information

Chemical Name:NEU-624
CAS No.:1432451-01-8
Molecular Formula:C₃₆H₃₅ClFN₅O₅S
Molecular Weight:704.222
Hs Code.:

Synonyms:NEU-624

Suppliers and Price of NEU-624

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of NEU-624

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Technology Process of NEU-624

There total 5 articles about NEU-624 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.7%

: 1042917-53-2
tert-butyl 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)piperazine-1-carboxylate

: N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine hydrochloride

: 1432451-01-8
NEU-624

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 85 ℃; for 12h;

Reference yield: 23.7%

: 851684-46-3
N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine hydrochloride

: 1042917-53-2
tert-butyl 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)piperazine-1-carboxylate

: 1432451-01-8
NEU-624

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 85 ℃; for 12h;
DOI:10.1021/jm400349k

Reference yield:

: 5326-47-6
2-amino-5-iodobenzoic acid

: 1432451-01-8
NEU-624

Guidance literature:: Multi-step reaction with 4 steps

1: 4 h / 170 °C

2: thionyl chloride / N,N-dimethyl-formamide / 12 h / 80 °C

3: isopropyl alcohol / 12 h / 80 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 12 h / 85 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm400349k