C₂₇H₃₀F₂N₆O₃S

Base Information

• Chemical Name: C₂₇H₃₀F₂N₆O₃S
• CAS No.: 1392429-39-8
• Molecular Formula: C₂₇H₃₀F₂N₆O₃S
• Molecular Weight: 556.636
• Mol file: 1392429-39-8.mol

Synonyms:C₂₇H₃₀F₂N₆O₃S

Chemical Property of C₂₇H₃₀F₂N₆O₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₃₀F₂N₆O₃S

There total 14 articles about C₂₇H₃₀F₂N₆O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + C26H28F2N6O3S (1392429-38-7) → C27H30F2N6O3S (1392429-39-8)

Guidance literature:

formaldehyd; C₂₆H₂₈F₂N₆O₃S; With sodium tris(acetoxy)borohydride; acetic acid; In water; N,N-dimethyl-formamide; at 20 ℃; for 72h;

With ammonia; In water; N,N-dimethyl-formamide; pH=8;

Reference yield:

6-chloro-4-methyl-3-nitropyridine (22280-60-0) → C27H30F2N6O3S (1392429-39-8)

Guidance literature:

Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 50 °C

2.1: N,N-dimethyl-formamide / 48 h / 90 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 3102.97 Torr / Autoclave

4.1: potassium phosphate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / copper(l) iodide / toluene / 16 h / 120 °C / Inert atmosphere

5.1: N-iodo-succinimide / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: sodium carbonate; lithium chloride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

7.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0.75 h / 20 °C

8.1: acetic acid; sodium tris(acetoxy)borohydride / N,N-dimethyl-formamide; water / 72 h / 20 °C

8.2: pH 8

With hydrogenchloride; potassium phosphate; N-iodo-succinimide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 4.1: Ullmann Reaction / 6.1: Suzuki Coupling;

Reference yield:

4-[6-((E)-2-(dimethylamino)vinyl)-5-nitropyridin-2-yl]piperazine-1-carboxylic acid tert-butyl ester (1392430-00-0) → C27H30F2N6O3S (1392429-39-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 3102.97 Torr / Autoclave

2.1: potassium phosphate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / copper(l) iodide / toluene / 16 h / 120 °C / Inert atmosphere

3.1: N-iodo-succinimide / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: sodium carbonate; lithium chloride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0.75 h / 20 °C

6.1: acetic acid; sodium tris(acetoxy)borohydride / N,N-dimethyl-formamide; water / 72 h / 20 °C

6.2: pH 8

With hydrogenchloride; potassium phosphate; N-iodo-succinimide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 2.1: Ullmann Reaction / 4.1: Suzuki Coupling;

upstream raw materials:

formaldehyd

C₂₆H₂₈F₂N₆O₃S

6-chloro-4-methyl-3-nitropyridine

4-(6-methyl-5-nitropyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester