Technology Process of tert-butyl 3-(2-(4-chloro-1H-imidazol-1-yl)-5-nitrophenoxy)propyl(methyl)carbamate
There total 6 articles about tert-butyl 3-(2-(4-chloro-1H-imidazol-1-yl)-5-nitrophenoxy)propyl(methyl)carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 18 h / 0 - 20 °C
2.1: caesium carbonate / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 18 h / 20 °C
3.1: potassium hydroxide / dimethyl sulfoxide / 18 h / 90 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C
4.2: 2 h / 70 °C
With
carbon tetrabromide; sodium hydride; caesium carbonate; triphenylphosphine; potassium hydroxide;
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: caesium carbonate / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 18 h / 20 °C
2.1: potassium hydroxide / dimethyl sulfoxide / 18 h / 90 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C
3.2: 2 h / 70 °C
With
sodium hydride; caesium carbonate; potassium hydroxide;
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C
2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 18 h / 0 - 20 °C
3.1: caesium carbonate / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 18 h / 20 °C
4.1: potassium hydroxide / dimethyl sulfoxide / 18 h / 90 °C
5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C
5.2: 2 h / 70 °C
With
carbon tetrabromide; sodium hydride; caesium carbonate; triethylamine; triphenylphosphine; potassium hydroxide;
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
