(R)-6-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

Base Information

Chemical Name:(R)-6-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine
CAS No.:1365214-74-9
Molecular Formula:C₁₆H₁₃F₃N₄
Molecular Weight:318.301
Hs Code.:

Synonyms:(R)-6-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

Suppliers and Price of (R)-6-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-6-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-6-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

There total 3 articles about (R)-6-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1223404-92-9
(2R,4R)-tert-butyl 2-(3-fluorophenyl)-4-hydroxypyrrolidine-1-carboxylate

: 1365214-74-9
(R)-6-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 1.25 h / -10 - 20 °C

2.1: diethylamino-sulfur trifluoride / dichloromethane / 2.5 h / -78 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.2: 0 °C

4.1: potassium fluoride / dimethyl sulfoxide / 120 °C

With potassium fluoride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; diethylamino-sulfur trifluoride; trichloroisocyanuric acid; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1223404-93-0
(R)-tert-butyl 2-(3-fluorophenyl)-4-oxopyrrolidine-1-carboxylate

: 1365214-74-9
(R)-6-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 2.5 h / -78 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2.2: 0 °C

3.1: potassium fluoride / dimethyl sulfoxide / 120 °C

With potassium fluoride; diethylamino-sulfur trifluoride; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1223404-95-2
(R)-tert-butyl 4,4-difluoro-2-(3-fluorophenyl)pyrrolidine-1-carboxylate

: 1365214-74-9
(R)-6-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

1.2: 0 °C

2.1: potassium fluoride / dimethyl sulfoxide / 120 °C

With potassium fluoride; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;