2-(Quinolin-5-yl)ethan-1-amine

Base Information

• Chemical Name: 2-(Quinolin-5-yl)ethan-1-amine
• CAS No.: 98421-28-4
• Molecular Formula: C₁₁H₁₂N₂
• Molecular Weight: 172.23
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID10695244
• Wikidata: Q82624368
• ChEMBL ID: CHEMBL4552762
• Mol file: 98421-28-4.mol

Synonyms:98421-28-4;2-(Quinolin-5-yl)ethan-1-amine;2-(QUINOLIN-5-YL)ETHANAMINE;2-quinolin-5-ylethanamine;SCHEMBL4394904;CHEMBL4552762;DTXSID10695244;AKOS006286575;SB68464;CS-0286438;FT-0695500;EN300-137682;1-(3,4-DIMETHOXYPHENYL)ETHAN-1-ONEOXIME

Chemical Property of 2-(Quinolin-5-yl)ethan-1-amine

Chemical Property:

• PSA: 38.91000
• LogP: 2.43630
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 172.100048391
• Heavy Atom Count: 13
• Complexity: 158

Purity/Quality:

98.5% ^*data from raw suppliers

2-(quinolin-5-yl)ethan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C2C=CC=NC2=C1)CCN

Technology Process of 2-(Quinolin-5-yl)ethan-1-amine

There total 7 articles about 2-(Quinolin-5-yl)ethan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(2-aminoethenyl)quinoline (98421-27-3) → 5-(2-aminoethyl)quinoline (98421-28-4)

Guidance literature:

With hydrogen; nickel; In methanol; at 25 ℃; for 1h; under 2585.7 Torr;

DOI:10.1021/jm00150a010

Reference yield:

quinoline-5-carbaldehyde (22934-41-4) → 5-(2-aminoethyl)quinoline (98421-28-4)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene / 1 h / Heating

2: AcOH / 0.5 h / Heating

3: 10.7 g / NaBH₄ / methanol / 0.5 h / 25 °C

4: H₂ / Raney Ni / methanol / 1 h / 25 °C / 2585.7 Torr

With sodium tetrahydroborate; hydrogen; acetic acid; nickel; In methanol; toluene;

DOI:10.1021/jm00150a010

Reference yield:

quinolin-5-ylmethanol (16178-42-0) → 5-(2-aminoethyl)quinoline (98421-28-4)

Guidance literature:

Multi-step reaction with 5 steps

1: MnO₂ / CHCl₃ / 3 h

2: toluene / 1 h / Heating

3: AcOH / 0.5 h / Heating

4: 10.7 g / NaBH₄ / methanol / 0.5 h / 25 °C

5: H₂ / Raney Ni / methanol / 1 h / 25 °C / 2585.7 Torr

With manganese(IV) oxide; sodium tetrahydroborate; hydrogen; acetic acid; nickel; In methanol; chloroform; toluene;

DOI:10.1021/jm00150a010

upstream raw materials:

5-(2-aminoethenyl)quinoline

quinoline-5-carbaldehyde

quinolin-5-ylmethanol

quinoline-5-carboxylic acid

Downstream raw materials:

5-(2-benzamidoethyl)quinoline

5-(2-benzamidoethyl)quinoline N-oxide

5-(2-benzamidoethyl)carbostyril