ethyl 8-chloro-7-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate

Base Information

Chemical Name:ethyl 8-chloro-7-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate
CAS No.:1414370-76-5
Molecular Formula:C₁₆H₁₂ClFN₂O₂
Molecular Weight:318.735
Hs Code.:

Synonyms:ethyl 8-chloro-7-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate

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Chemical Property of ethyl 8-chloro-7-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate

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Technology Process of ethyl 8-chloro-7-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate

There total 4 articles about ethyl 8-chloro-7-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1414371-26-8
ethyl 8-chloro-7-iodoimidazo[1,2-a]pyridine-2-carboxylate

: 1765-93-1
4-fluoroboronic acid

: 1414370-76-5
ethyl 8-chloro-7-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In tetrahydrofuran; water; at 75 ℃; regioselective reaction;
DOI:10.3390/molecules170910683

Reference yield:

: 889865-45-6
2,3-dichloro-4-iodopyridine

: 1414370-76-5
ethyl 8-chloro-7-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium hydroxide / 16 h / 129 °C

2.1: 1,2-dimethoxyethane / 20 °C

2.2: 2 h / 78 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / tetrahydrofuran; water / 75 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium hydroxide; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; 3.1: |Suzuki Coupling;
DOI:10.3390/molecules170910683

Reference yield:

: 1152617-24-7
2-amino-3-chloro-4-iodopyridine

: 1414370-76-5
ethyl 8-chloro-7-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,2-dimethoxyethane / 20 °C

1.2: 2 h / 78 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / tetrahydrofuran; water / 75 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; 2.1: |Suzuki Coupling;
DOI:10.3390/molecules170910683