4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

Base Information

• Chemical Name: 4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester
• CAS No.: 869063-72-9
• Molecular Formula: C₂₄H₂₉NO₇S
• Molecular Weight: 475.563

Synonyms:4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

Chemical Property of 4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

Chemical Property:

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Technology Process of 4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

There total 4 articles about 4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-tert-butyl 4-ethyl 4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1,4-dicarboxylate (213014-04-1) → 4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (869063-72-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; ethanol; at 60 ℃; for 18h;

DOI:10.1021/jm0500875

Reference yield:

4-(iodomethyl)piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (213013-98-0) → 4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (869063-72-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.25 h / 0 °C

1.2: 89 percent / dimethylformamide / 4 h / 0 - 20 °C

2.1: 97 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 2 h / 0 °C

3.1: 100 percent / aq. NaOH / ethanol; tetrahydrofuran / 18 h / 60 °C

With sodium hydroxide; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0500875

Reference yield:

4-(4-phenoxy-phenylsulfanylmethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (213014-03-0) → 4-(4-phenoxy-benzenesulfonylmethyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (869063-72-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 2 h / 0 °C

2: 100 percent / aq. NaOH / ethanol; tetrahydrofuran / 18 h / 60 °C

With sodium hydroxide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm0500875

upstream raw materials:

1-tert-butyl 4-ethyl 4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1,4-dicarboxylate

4-(iodomethyl)piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

4-(4-phenoxy-phenylsulfanylmethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

Downstream raw materials:

tert-butyl 4-[(hydroxyamino)carbonyl]-4-{[(4-phenoxyphenyl)sulfonyl]methyl}piperidine-1-carboxylate

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