methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-nitrophenyl]acetate

Base Information

Chemical Name:methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-nitrophenyl]acetate
CAS No.:1403381-25-8
Molecular Formula:C₂₂H₂₅NO₆
Molecular Weight:399.444
Hs Code.:

Synonyms:methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-nitrophenyl]acetate

Suppliers and Price of methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-nitrophenyl]acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-nitrophenyl]acetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-nitrophenyl]acetate

There total 8 articles about methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-nitrophenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1002727-88-9
2-(chroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1403381-24-7
methyl 2-(tert-butoxy)-2-(2-chloro-5-nitrophenyl)acetate

methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-nitrophenyl]acetate: 1403381-25-8
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-nitrophenyl]acetate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 85 ℃;

Reference yield:

: 114776-15-7
2-chloro-4-fluoro-5-nitrobenzoic acid

methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-nitrophenyl]acetate: 1403381-25-8
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-nitrophenyl]acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: triethylamine; magnesium chloride / acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere

2.2: 20 °C

2.3: 6 h / Reflux

3.1: selenium(IV) oxide / ytterbium(III) triflate / 1,4-dioxane; water / 48 h / 90 °C

3.2: 3 h / Reflux

4.1: perchloric acid / 3 h / -20 - 20 °C

5.1: ammonia / methanol / 0.5 h / 60 °C

6.1: tert.-butylnitrite / N,N-dimethyl-formamide / 1 h / 60 °C

7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 85 °C

With selenium(IV) oxide; thionyl chloride; tert.-butylnitrite; perchloric acid; ammonia; sodium carbonate; triethylamine; magnesium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ytterbium(III) triflate; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 2252-51-9
2-choro-4-fluorobenzoic acid

methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-nitrophenyl]acetate: 1403381-25-8
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-nitrophenyl]acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium nitrate; sulfuric acid / 4 h / 0 - 20 °C

2.1: thionyl chloride / 2 h / Reflux

3.1: triethylamine; magnesium chloride / acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere

3.2: 20 °C

3.3: 6 h / Reflux

4.1: selenium(IV) oxide / ytterbium(III) triflate / 1,4-dioxane; water / 48 h / 90 °C

4.2: 3 h / Reflux

5.1: perchloric acid / 3 h / -20 - 20 °C

6.1: ammonia / methanol / 0.5 h / 60 °C

7.1: tert.-butylnitrite / N,N-dimethyl-formamide / 1 h / 60 °C

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 85 °C

With selenium(IV) oxide; thionyl chloride; tert.-butylnitrite; perchloric acid; sulfuric acid; ammonia; sodium carbonate; potassium nitrate; triethylamine; magnesium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ytterbium(III) triflate; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;