(4R,5S)-6-(tert-butyldimethylsilanyloxy)-4-benzyloxy-5-dibenzylaminohexanal

Base Information

Chemical Name:(4R,5S)-6-(tert-butyldimethylsilanyloxy)-4-benzyloxy-5-dibenzylaminohexanal
CAS No.:349556-02-1
Molecular Formula:C₃₃H₄₅NO₃Si
Molecular Weight:531.811
Hs Code.:

Synonyms:(4R,5S)-6-(tert-butyldimethylsilanyloxy)-4-benzyloxy-5-dibenzylaminohexanal

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Chemical Property of (4R,5S)-6-(tert-butyldimethylsilanyloxy)-4-benzyloxy-5-dibenzylaminohexanal

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Technology Process of (4R,5S)-6-(tert-butyldimethylsilanyloxy)-4-benzyloxy-5-dibenzylaminohexanal

There total 5 articles about (4R,5S)-6-(tert-butyldimethylsilanyloxy)-4-benzyloxy-5-dibenzylaminohexanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 349555-96-0
(2S,3R)-1-(tert-butyldimethylsilanyloxy)-2-dibenzylamino-3-benzyloxy-5-[1,3]dioxolan-2-yl-pentane

: 349556-02-1
(4R,5S)-6-(tert-butyldimethylsilanyloxy)-4-benzyloxy-5-dibenzylaminohexanal

Guidance literature:: (2S,3R)-1-(tert-butyldimethylsilanyloxy)-2-dibenzylamino-3-benzyloxy-5-[1,3]dioxolan-2-yl-pentane; With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 4h;

tert-butyldimethylsilyl chloride; With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.3987/COM-04-S(P)21

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 349555-97-1
(4R,5S)-4-Benzyloxy-5-dibenzylamino-6-hydroxy-hexanal

: 349556-02-1
(4R,5S)-6-(tert-butyldimethylsilanyloxy)-4-benzyloxy-5-dibenzylaminohexanal

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0040-4039(01)00483-X

Reference yield:

: 125654-82-2
(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-dibenzylamino-propionaldehyde

: 349556-02-1
(4R,5S)-6-(tert-butyldimethylsilanyloxy)-4-benzyloxy-5-dibenzylaminohexanal

Guidance literature:: Multi-step reaction with 3 steps

1.1: Mg / tetrahydrofuran / 1 h / 20 °C

1.2: 86 percent / tetrahydrofuran / 1 h / 20 °C

2.1: 85 percent / NaH; Bu₄NI / tetrahydrofuran / 12 h / 20 °C

3.1: HCl / tetrahydrofuran; H₂O / 4 h / 20 °C

3.2: 90 percent / imidazole / dimethylformamide / 20 °C

With hydrogenchloride; tetra-(n-butyl)ammonium iodide; sodium hydride; magnesium; In tetrahydrofuran; water;
DOI:10.3987/COM-04-S(P)21