5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-ylamine

Base Information

• Chemical Name: 5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-ylamine
• CAS No.: 1469858-61-4
• Molecular Formula: C₂₆H₃₀N₄O₂SSi
• Molecular Weight: 490.701

Synonyms:5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-ylamine

Chemical Property of 5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of 5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-ylamine

There total 7 articles about 5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

5-(3-(4-methoxyphenyl)-1,4-dihydrothieno[2',3':4,5]cyclopenta[1,2-c]pyrazol-6-yl)pyridin-2-amine (1469857-88-2) + (2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → 5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-ylamine (1469858-61-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 80 ℃;

Reference yield: 60.0%

2-aminopyridine-5-boronic acid pinacol ester (827614-64-2) + 2-bromo-6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene (1469858-46-5) → 5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-ylamine (1469858-61-4)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In ethanol; toluene; at 100 ℃; for 8h;

Reference yield:

2-bromo-6-(4-methoxyphenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene (1469857-45-1) → 5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-ylamine (1469858-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 80 °C

2: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene / 8 h / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium hydride; sodium carbonate; In tetrahydrofuran; ethanol; toluene; mineral oil;

upstream raw materials:

2-bromo-6-(4-methoxyphenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

phenyl 4-methoxybenzoate

6-(4-methoxyphenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

5,6-dihydro-<6H>-cyclopenta--thiophene-4-one

Downstream raw materials:

5-[6-(4-methoxyphenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-ylamine hydrochloride

N-{5-[6-(4-methoxyphenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

N-{5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

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