3'-deoxy-3'-(2,4-dinitrophenyldisulfanyl)-5'-O-(monomethoxytrityl)thymidine

Base Information

• Chemical Name: 3'-deoxy-3'-(2,4-dinitrophenyldisulfanyl)-5'-O-(monomethoxytrityl)thymidine
• CAS No.: 142827-02-9
• Molecular Formula: C₃₆H₃₂N₄O₉S₂
• Molecular Weight: 728.803
• Mol file: 142827-02-9.mol

Synonyms:3'-deoxy-3'-(2,4-dinitrophenyldisulfanyl)-5'-O-(monomethoxytrityl)thymidine

Chemical Property of 3'-deoxy-3'-(2,4-dinitrophenyldisulfanyl)-5'-O-(monomethoxytrityl)thymidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-deoxy-3'-(2,4-dinitrophenyldisulfanyl)-5'-O-(monomethoxytrityl)thymidine

There total 1 articles about 3'-deoxy-3'-(2,4-dinitrophenyldisulfanyl)-5'-O-(monomethoxytrityl)thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2,4-dinitrobenzenesulfenyl chloride (528-76-7) + 5′-O-(mono-p-methoxytriphenylmethyl)-3′-deoxy-3′-thiothymidine (119005-68-4) → 3'-deoxy-3'-(2,4-dinitrophenyldisulfanyl)-5'-O-(monomethoxytrityl)thymidine (142827-02-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 ℃; for 1.5h;

DOI:10.1016/S0040-4039(00)79587-6

Reference yield: 94.0%

3'-deoxy-3'-(2,4-dinitrophenyldisulfanyl)-5'-O-(monomethoxytrityl)thymidine (142827-02-9) + 3'-O-acetylthymidin-5'-yl 2,4-dimethoxybenzylmethyl phosphite (161790-57-4) → C43H47N4O13PS (142827-04-1)

Guidance literature:

In toluene; for 2h; Ambient temperature;

Reference yield: 94.0%

3'-deoxy-3'-(2,4-dinitrophenyldisulfanyl)-5'-O-(monomethoxytrityl)thymidine (142827-02-9) + 3'-O-acetylthymidin-5'-yl 2-cyanoethyl 2,4-dimethoxybenzyl phosphite → C45H48N5O13PS (119009-80-2)

Guidance literature:

In toluene; for 24h; Ambient temperature;

upstream raw materials:

2,4-dinitrobenzenesulfenyl chloride

5′-O-(mono-p-methoxytriphenylmethyl)-3′-deoxy-3′-thiothymidine

Downstream raw materials:

C₄₃H₄₇N₄O₁₃PS

C₄₇H₅₉N₄O₁₂PSSi

C₄₅H₄₈N₅O₁₃PS

O,O-dimethyl 5'-O-monomethoxytrityl-3'-thiothymidin-3'-yl phosphorothiolate