Thymidine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-3'-thio-, 3'-(dimethyl phosphate)

Base Information

• Chemical Name: Thymidine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-3'-thio-, 3'-(dimethyl phosphate)
• CAS No.: 142827-03-0
• Molecular Formula: C₃₂H₃₅N₂O₈PS
• Molecular Weight: 638.678
• Mol file: 142827-03-0.mol

Synonyms:

Chemical Property of Thymidine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-3'-thio-, 3'-(dimethyl phosphate)

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thymidine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-3'-thio-, 3'-(dimethyl phosphate)

There total 3 articles about Thymidine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-3'-thio-, 3'-(dimethyl phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3'-deoxy-3'-(2,4-dinitrophenyldisulfanyl)-5'-O-(monomethoxytrityl)thymidine (142827-02-9) + phosphorous acid trimethyl ester (121-45-9) → O,O-dimethyl 5'-O-monomethoxytrityl-3'-thiothymidin-3'-yl phosphorothiolate (142827-03-0)

Guidance literature:

In tetrahydrofuran; for 20h; Ambient temperature;

Reference yield:

5′-O-(mono-p-methoxytriphenylmethyl)-3′-deoxy-3′-thiothymidine (119005-68-4) → O,O-dimethyl 5'-O-monomethoxytrityl-3'-thiothymidin-3'-yl phosphorothiolate (142827-03-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temperature, 1 h

2: 83 percent / tetrahydrofuran / 20 h / Ambient temperature

In tetrahydrofuran;

Reference yield:

3'-deoxy-5'-O-monomethoxytrityl-3'-S-(2-nitrophenyldisulfanyl)thymidine (142827-01-8) + phosphorous acid trimethyl ester (121-45-9) → O,O-dimethyl 5'-O-monomethoxytrityl-3'-thiothymidin-3'-yl phosphorothiolate (142827-03-0)

Guidance literature:

In tetrahydrofuran; Yield given; Ambient temperature;

DOI:10.1016/S0040-4039(00)79587-6

upstream raw materials:

3'-deoxy-5'-O-monomethoxytrityl-3'-S-(2-nitrophenyldisulfanyl)thymidine

phosphorous acid trimethyl ester

3'-deoxy-3'-(2,4-dinitrophenyldisulfanyl)-5'-O-(monomethoxytrityl)thymidine

5′-O-(mono-p-methoxytriphenylmethyl)-3′-deoxy-3′-thiothymidine