3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile

Base Information

• Chemical Name: 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile
• CAS No.: 1093254-29-5
• Molecular Formula: C₁₄H₉Cl₂FN₂O
• Molecular Weight: 311.143
• Mol file: 1093254-29-5.mol

Synonyms:3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile

Chemical Property of 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile

There total 10 articles about 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-{[3-(bromomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile (1089178-83-5) → 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile (1093254-29-5)

Guidance literature:

With ammonia; In methanol; dichloromethane; for 2h;

DOI:10.1021/jm301294g

Reference yield: 82.0%

3-chloro-5-({6-chloro-3-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile (1093260-81-1) → 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile (1093254-29-5)

Guidance literature:

With hydrazine hydrate; In methanol; at 60 ℃; for 2h;

Reference yield:

bis(1,1-dimethylethyl) {3-[(3-chloro-5-cyanophenyl)oxy]-2-fluoro-4-nitrophenyl}propanedioate (1093260-71-9) → 3-{[3-(aminomethyl)-6-chloro-2-fluorophenyl]oxy}-5-chlorobenzonitrile (1093254-29-5)

Guidance literature:

Multi-step reaction with 6 steps

1: trifluoroacetic acid / dichloromethane / 2 h / Reflux

2: copper(I) oxide / acetonitrile / 2 h / Reflux

3: sodium dithionite; water / tetrahydrofuran / 1 h

4: copper dichloride; tert.-butylnitrite / acetonitrile / 0.5 h / 50 °C / Inert atmosphere

5: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 85 °C

6: ammonia / dichloromethane; methanol / 2 h

With copper(I) oxide; N-Bromosuccinimide; tert.-butylnitrite; sodium dithionite; 2,2'-azobis(isobutyronitrile); ammonia; water; trifluoroacetic acid; copper dichloride; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; acetonitrile;

DOI:10.1021/jm301294g

upstream raw materials:

bis(1,1-dimethylethyl) {3-[(3-chloro-5-cyanophenyl)oxy]-2-fluoro-4-nitrophenyl}propanedioate

3-chloro-5-[(2-fluoro-3-methyl-6-nitrophenyl)oxy]benzonitrile

3-[(6-amino-2-fluoro-3-methylphenyl)oxy]-5-chlorobenzonitrile

3-chloro-5-[(6-chloro-2-fluoro-3-methylphenyl)oxy]benzonitrile

Downstream raw materials:

4-(aminosulfonyl)-2-chloro-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)benzamide

N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1-benzofuran-2-carboxamide

N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-indole-2-carboxamide

N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-benzimidazole-2-carboxamide