1312581-05-7Relevant articles and documents
Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors – Part I
Barberis, Claude,Moorcroft, Neil,Arendt, Chris,Levit, Mikhail,Moreno-Mazza, Sandra,Batchelor, Joseph,Mechin, Ingrid,Majid, Tahir
, p. 4730 - 4734 (2017)
Novel N-substituted azaindoles have been discovered as PIM1 inhibitors. X-ray structures have played a significant role in orienting the chemistry effort in the initial phase of hit confirmation. Disclosure of an unconventional binding mode for 1 and 2, as demonstrated by X-ray crystallography, is presented and was an important factor in selecting and advancing a lead series.