1312581-05-7

Upstream product

• 55052-28-3 4-chloro-7-azaindole 

Downstream Products

• 1312581-15-9 4-[4-(4-chloro-1-methoxymethyl-7-azaindole)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1312581-11-5 4-[4-(4-chloro-3-iodo-1-methyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1312579-40-0 3-[4-chloro-1-methyl-2-(4-piperazin-1-yl-phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-N-(2-dimethylamino-ethyl)-benzamide 
• 1312581-10-4 4-[4-(4-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1312581-09-1 4-chloro-2-iodo-1-methyl-1H-pyrrolo[2,3-b]pyridine 
• 1312580-89-4 4-{4-chloro-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-7-azaindole}-benzoic acid ethyl ester 
• 1312581-19-3 4-{4-chloro-1-methoxymethyl-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-7-azaindole}-benzoic acid ethyl ester 
• 1312581-17-1 4-{4-[4-chloro-3-(4-ethoxycarbonyl-phenyl)-1-methoxymethyl-7-azaindole]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 1312581-16-0 4-[4-(4-chloro-3-iodo-1-methoxymethyl-7-azaindole)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1312580-69-0 (4-{4-chloro-1-cyclobutylmethyl-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-7-azaindole}-phenyl)-methanol 
• 1312581-14-8 4-{4-chloro-1-cyclobutylmethyl-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-7-azaindole}-benzoic acid ethyl ester 
• 940948-29-8 4-chloro-2-iodo-1H-pyrrolo[2,3-b]pyridine 

Relevant academic research and scientific papers

Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors – Part I

Novel N-substituted azaindoles have been discovered as PIM1 inhibitors. X-ray structures have played a significant role in orienting the chemistry effort in the initial phase of hit confirmation. Disclosure of an unconventional binding mode for 1 and 2, as demonstrated by X-ray crystallography, is presented and was an important factor in selecting and advancing a lead series.

AZAINDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

The disclosure relates generally to compounds that inhibit Pim kinases. Provided herein are N-substituted azaindoles, or pharmaceutically acceptable salts thereof, which are useful as selective inhibitors of Pim kinases. The disclosure also relates to pharmaceutical compositions comprising these compounds, processes for their preparation, and methods of using the same.