N-{[(prop-2-en-1-yl)oxy]carbonyl}-L-valyl-N-[4-({[(2-[(2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl]-4-methoxy-5-{[tri(propan-2-yl)silyl]oxy}phenyl)carbamoyl]oxy}methyl)phenyl]-L-alaninamide

Base Information

Chemical Name:N-{[(prop-2-en-1-yl)oxy]carbonyl}-L-valyl-N-[4-({[(2-[(2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl]-4-methoxy-5-{[tri(propan-2-yl)silyl]oxy}phenyl)carbamoyl]oxy}methyl)phenyl]-L-alaninamide
CAS No.:1430738-30-9
Molecular Formula:C₄₉H₇₇N₅O₁₀Si₂
Molecular Weight:952.349
Hs Code.:

N-{[(prop-2-en-1-yl)oxy]carbonyl}-L-valyl-N-[4-({[(2-[(2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl]-4-methoxy-5-{[tri(propan-2-yl)silyl]oxy}phenyl)carbamoyl]oxy}methyl)phenyl]-L-alaninamide

Synonyms:N-{[(prop-2-en-1-yl)oxy]carbonyl}-L-valyl-N-[4-({[(2-[(2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl]-4-methoxy-5-{[tri(propan-2-yl)silyl]oxy}phenyl)carbamoyl]oxy}methyl)phenyl]-L-alaninamide

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Chemical Property of N-{[(prop-2-en-1-yl)oxy]carbonyl}-L-valyl-N-[4-({[(2-[(2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl]-4-methoxy-5-{[tri(propan-2-yl)silyl]oxy}phenyl)carbamoyl]oxy}methyl)phenyl]-L-alaninamide

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Technology Process of N-{[(prop-2-en-1-yl)oxy]carbonyl}-L-valyl-N-[4-({[(2-[(2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl]-4-methoxy-5-{[tri(propan-2-yl)silyl]oxy}phenyl)carbamoyl]oxy}methyl)phenyl]-L-alaninamide

There total 32 articles about N-{[(prop-2-en-1-yl)oxy]carbonyl}-L-valyl-N-[4-({[(2-[(2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl]-4-methoxy-5-{[tri(propan-2-yl)silyl]oxy}phenyl)carbamoyl]oxy}methyl)phenyl]-L-alaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1343407-91-9
allyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1- oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

: 1430738-23-0
(S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl) ( 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrol-1-yl)methanone

: 530-62-1
1,1'-carbonyldiimidazole

: 1430738-30-9
N-{[(prop-2-en-1-yl)oxy]carbonyl}-L-valyl-N-[4-({[(2-[(2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl]-4-methoxy-5-{[tri(propan-2-yl)silyl]oxy}phenyl)carbamoyl]oxy}methyl)phenyl]-L-alaninamide

Guidance literature:: (S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl) ( 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrol-1-yl)methanone; 1,1'-carbonyldiimidazole; In 1,2-dichloro-ethane; at 23 ℃; for 0.5h;

allyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-carbamate; In 1,2-dichloro-ethane; at 80 ℃; for 120h;
DOI:10.1021/acs.joc.8b02876

Reference yield: 50.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1343407-91-9
allyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1- oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

: 1430738-23-0
(S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl) ( 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrol-1-yl)methanone

: 1430738-30-9
N-{[(prop-2-en-1-yl)oxy]carbonyl}-L-valyl-N-[4-({[(2-[(2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl]-4-methoxy-5-{[tri(propan-2-yl)silyl]oxy}phenyl)carbamoyl]oxy}methyl)phenyl]-L-alaninamide

Guidance literature:: bis(trichloromethyl) carbonate; (S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl) ( 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrol-1-yl)methanone; With triethylamine; In tetrahydrofuran; at 5 ℃;

allyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-carbamate; With triethylamine; In tetrahydrofuran; at 40 ℃; for 4h;

Reference yield: 50.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: Alloc-Val-ala-PAB-OH

: 1430738-23-0
(S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl) ( 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrol-1-yl)methanone

: 1430738-30-9
N-{[(prop-2-en-1-yl)oxy]carbonyl}-L-valyl-N-[4-({[(2-[(2S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl]-4-methoxy-5-{[tri(propan-2-yl)silyl]oxy}phenyl)carbamoyl]oxy}methyl)phenyl]-L-alaninamide

Guidance literature:: bis(trichloromethyl) carbonate; (S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl) ( 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrol-1-yl)methanone; With triethylamine; In tetrahydrofuran; at 5 ℃;

Alloc-Val-ala-PAB-OH; With triethylamine; In tetrahydrofuran; at 40 ℃; for 4h;