N-allyl-1-benzyl-7-cyano-N-(2,2-diethoxy-1-phenylethyl)-2-indolecarboxamide

Base Information

Chemical Name:N-allyl-1-benzyl-7-cyano-N-(2,2-diethoxy-1-phenylethyl)-2-indolecarboxamide
CAS No.:157422-72-5
Molecular Formula:C₃₂H₃₃N₃O₃
Molecular Weight:507.632
Hs Code.:

Synonyms:N-allyl-1-benzyl-7-cyano-N-(2,2-diethoxy-1-phenylethyl)-2-indolecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-allyl-1-benzyl-7-cyano-N-(2,2-diethoxy-1-phenylethyl)-2-indolecarboxamide

Chemical Property:

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Technology Process of N-allyl-1-benzyl-7-cyano-N-(2,2-diethoxy-1-phenylethyl)-2-indolecarboxamide

There total 29 articles about N-allyl-1-benzyl-7-cyano-N-(2,2-diethoxy-1-phenylethyl)-2-indolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-37-8
oxalyl dichloride

: 157422-73-6
N-allyl-2,2-diethoxy-1-phenylethylamine

: 157422-71-4
1-benzyl-7-cyanoindole-2-carboxylic acid

: 157422-72-5
N-allyl-1-benzyl-7-cyano-N-(2,2-diethoxy-1-phenylethyl)-2-indolecarboxamide

Guidance literature:: With triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 6175-45-7
2,2-diethoxyacetophenone

: 157422-72-5
N-allyl-1-benzyl-7-cyano-N-(2,2-diethoxy-1-phenylethyl)-2-indolecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) acetic acid, 3 Angstroem molecular sieves, 2.) NaBH₃CN / 1.) ethanol, 1 h, 2.) ethanol, RT, 2 d

2: triethylamine / CH₂Cl₂

With 3 A molecular sieve; sodium cyanoborohydride; acetic acid; triethylamine; In dichloromethane;
DOI:10.1021/jm00001a014

Reference yield:

: 1-Benzyl-7-formyl-1H-indole-2-carboxylic acid

: 157422-72-5
N-allyl-1-benzyl-7-cyano-N-(2,2-diethoxy-1-phenylethyl)-2-indolecarboxamide

Guidance literature:: Multi-step reaction with 13 steps

1: oxalyl chloride, N,N-dimethylformamide / CH₂Cl₂ / 1 h

2: triethylamine / CH₂Cl₂

3: conc. sulfuric acid / diethyl ether / 3 h

4: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) THF, H₂O, overnight, 2.) ethanol, H₂O, 2 h

5: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s); H₂O / 0.5 h

6: 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide

7: nitromethane, aluminum chloride / benzene / 1 h

8: sodium chlorite, sodium dihydrogen phosphate / 2-methyl-propan-2-ol; tetrahydrofuran; various solvent(s); H₂O / 0.5 h

9: 48 percent / methanol; diethyl ether

10: 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide, dichloroacetic acid / dimethylsulfoxide; toluene / 2 h / Ambient temperature

11: lithium hydroxide / tetrahydrofuran; methanol; H₂O / 1 h

12: oxalyl chloride, N,N-dimethylformamide / CH₂Cl₂ / 1 h

13: triethylamine / CH₂Cl₂

With dichloro-acetic acid; lithium hydroxide; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; aluminium trichloride; sodium dihydrogen phosphate; oxalyl dichloride; nitromethane; sulfuric acid; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4-methylmorpholine N-oxide; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; benzene;
DOI:10.1021/jm00001a014