Technology Process of (R)-tert-butyl 3-benzyl-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate
There total 10 articles about (R)-tert-butyl 3-benzyl-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
dichloromethane;
at 0 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: dichloromethane / 0 - 20 °C
2.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 0 - 20 °C / Inert atmosphere
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
3.2: 4 h / 60 °C
4.1: lithium hydroxide monohydrate / tetrahydrofuran / 55 °C
5.1: hydrogenchloride / methanol; ethyl acetate / 1 h / 20 °C
6.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C
7.1: lithium aluminium tetrahydride / tetrahydrofuran / 30 h / Reflux
8.1: dichloromethane / 0 - 20 °C
With
hydrogenchloride; lithium aluminium tetrahydride; lithium hydroxide monohydrate; carbon tetrabromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
1.2: 4 h / 60 °C
2.1: lithium hydroxide monohydrate / tetrahydrofuran / 55 °C
3.1: hydrogenchloride / methanol; ethyl acetate / 1 h / 20 °C
4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 30 h / Reflux
6.1: dichloromethane / 0 - 20 °C
With
hydrogenchloride; lithium aluminium tetrahydride; lithium hydroxide monohydrate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
