N-methyl-1-(5-methylthiophen-2-yl)methanamine

Base Information

• Chemical Name: N-methyl-1-(5-methylthiophen-2-yl)methanamine
• CAS No.: 82230-49-7
• Molecular Formula: C₇H₁₁NS
• Molecular Weight: 141.237
• DSSTox Substance ID: DTXSID00359383
• Wikidata: Q82140575
• ChEMBL ID: CHEMBL3781201
• Mol file: 82230-49-7.mol

Synonyms:82230-49-7;N-methyl-1-(5-methylthiophen-2-yl)methanamine;N-methyl-1-(5-methyl-2-thienyl)methanamine;methyl[(5-methylthiophen-2-yl)methyl]amine;CHEMBL3781201;2-methyl-5-[(methylamino)methyl]thiophene;Methyl-(5-methyl-thiophen-2-ylmethyl)-amine;SCHEMBL7004098;DTXSID00359383;BDBM50158085;MFCD04577955;AKOS002615238;TS-01845;EN300-145350;F2169-1270

Chemical Property of N-methyl-1-(5-methylthiophen-2-yl)methanamine

Chemical Property:

• Storage Temp.: 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 141.06122053
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

98% ^*data from raw suppliers

Methyl-(5-methyl-thiophen-2-ylmethyl)-amine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(S1)CNC
• Uses: N-Methyl-1-(5-methyl-2-thienyl)methanamine is used in the preparation of adamantyl carboxamides and acetamides which are potent human 11β-?hydroxysteroid dehydrogenase type 1 inhibitors.

Technology Process of N-methyl-1-(5-methylthiophen-2-yl)methanamine

There total 3 articles about N-methyl-1-(5-methylthiophen-2-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

5-methylthiophene-2-carboxaldehyde (13679-70-4) + methylamine (74-89-5) → 5-methyl-2-<(methylamino)methyl>thiophene (82230-49-7)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; In methanol; at 20 ℃;

DOI:10.1021/jo050368k

Reference yield:

5-methylthiophene-2-carboxaldehyde (13679-70-4) + methylamine hydrochloride (593-51-1) → 5-methyl-2-<(methylamino)methyl>thiophene (82230-49-7)

Guidance literature:

methylamine hydrochloride; With potassium carbonate; In methanol; at 20 ℃; for 0.5h;

5-methylthiophene-2-carboxaldehyde; In methanol; at 20 ℃; for 1h;

With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 3h;

DOI:10.1021/acs.jmedchem.6b01196

Reference yield:

2-Methylthiophene (554-14-3) + methylamine hydrochloride (593-51-1) → 5-methyl-2-<(methylamino)methyl>thiophene (82230-49-7)

Guidance literature:

With formaldehyd;

upstream raw materials:

2-Methylthiophene

methylamine hydrochloride

5-methylthiophene-2-carboxaldehyde

methylamine

Downstream raw materials:

2,6-dimethyl-4-phenyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine

2,6-dimethyl-4-(p-bromophenyl)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine

4-(4-hydroxyphenyl)-2,6-dimethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

1-(4-Bromo-phenyl)-2-[methyl-(5-methyl-thiophen-2-ylmethyl)-amino]-ethanol

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