(S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate

Base Information

• Chemical Name: (S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate
• CAS No.: 920739-17-9
• Molecular Formula: C₃₀H₃₀ClNO₄S
• Molecular Weight: 536.091
• Mol file: 920739-17-9.mol

Synonyms:(S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate

Chemical Property of (S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate

There total 1 articles about (S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-(2-(3-(3(R)-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propanol) (150026-75-8) + methanesulfonyl chloride (124-63-0) → (S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate (920739-17-9)

Guidance literature:

(2-(2-(3-(3(R)-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propanol); With N-ethyl-N,N-diisopropylamine; In toluene; acetonitrile; at -15 - 80 ℃; for 0.25 - 0.5h;

methanesulfonyl chloride; In toluene; acetonitrile; at -13 ℃; for 9 - 9.5h; Product distribution / selectivity;

Reference yield:

(S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate (920739-17-9) + N-cyclohexyl-cyclohexanamine (101-83-7) + 1-(sulfanylmethyl)cyclopropaneacetic acid (162515-68-6) → 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt (577953-88-9)

Guidance literature:

1-(sulfanylmethyl)cyclopropaneacetic acid; With sodium methylate; In methanol; dimethyl sulfoxide; at -5 - 0 ℃; for 1h;

(S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate; In methanol; water; dimethyl sulfoxide; at -5 - 20 ℃; for 10.5h;

N-cyclohexyl-cyclohexanamine; With sodium hydroxide; acetic acid; more than 3 stages; Product distribution / selectivity;

Reference yield:

(S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate (920739-17-9) + 1-(sulfanylmethyl)cyclopropaneacetic acid (162515-68-6) → montelukast (158966-92-8)

Guidance literature:

1-(sulfanylmethyl)cyclopropaneacetic acid; With n-butyllithium; In tetrahydrofuran; hexane; at -15 ℃; for 0.5h;

(S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate; In tetrahydrofuran; hexane; for 1h; Product distribution / selectivity;

upstream raw materials:

(2-(2-(3-(3(R)-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propanol)

methanesulfonyl chloride

Downstream raw materials:

montelukast

2-(1-((((R)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propyl)sulfanyl)methyl)cyclopropyl)acetonitrile

1-(((1(R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid methyl ester

montelukast tert-butylamine salt

Refernces

• 1、 -. "PROCESS FOR PREPARING MONTELUKAST AND SALTS THEREOF USING OPTICALLY IMPURE 2-(2-(3(S)-(3-(7-CHLORO-2-QUINOLINYL)ETHENYL)PHENYL)-3-HYDROXYPROPYL)PHENYL-2-PROPANOL". Page/Page column 12. . Retrieved 2008/12/08.