2-(3,3-dimethylbut-1-yl)amino-2'-fluorodiphenylamine

Base Information

• Chemical Name: 2-(3,3-dimethylbut-1-yl)amino-2'-fluorodiphenylamine
• CAS No.: 151385-67-0
• Molecular Formula: C₁₈H₂₃FN₂
• Molecular Weight: 286.392
• Mol file: 151385-67-0.mol

Synonyms:2-(3,3-dimethylbut-1-yl)amino-2'-fluorodiphenylamine

Chemical Property of 2-(3,3-dimethylbut-1-yl)amino-2'-fluorodiphenylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,3-dimethylbut-1-yl)amino-2'-fluorodiphenylamine

There total 1 articles about 2-(3,3-dimethylbut-1-yl)amino-2'-fluorodiphenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3,3-dimethylbutyrylaldehyde (2987-16-8) + N-(2-fluorophenyl)benzene-1,2-diamine (28898-03-5) → 2-(3,3-dimethylbut-1-yl)amino-2'-fluorodiphenylamine (151385-67-0)

Guidance literature:

With sodium tetrahydroborate; sodium acetate; In ethanol; water; acetic acid; at 23 ℃; for 0.5h;

DOI:10.1021/jm990967h

Reference yield:

2-(3,3-dimethylbut-1-yl)amino-2'-fluorodiphenylamine (151385-67-0) → N-[1-(3,3-Dimethylbut-1-yl)-2,4-dioxo-5-(2-fluorophenyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl]-N'-(3-methylmercapto)phenylurea

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran / 3 h / 50 °C

2: Zn; AcOH / 3 h / 23 °C

3: toluene; CH₂Cl₂ / 4 h / 23 °C

4: acetonitrile / 7 h

With acetic acid; zinc; In tetrahydrofuran; dichloromethane; toluene; acetonitrile; 1: Acylation / 2: Reduction / 3: Carbonylation / 4: Addition;

DOI:10.1021/jm990967h

Reference yield:

2-(3,3-dimethylbut-1-yl)amino-2'-fluorodiphenylamine (151385-67-0) → N-[1-(3,3-Dimethylbut-1-yl)-2,4-dioxo-5-(2-fluorophenyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin.-3-yl]-N'-(3-dimethylamino)phenylurea

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran / 3 h / 50 °C

2: Zn; AcOH / 3 h / 23 °C

3: pyridine / CH₂Cl₂ / 0.5 h / 23 °C

4: Et₃N / dimethylformamide / 2 h / 160 °C

With pyridine; acetic acid; triethylamine; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Acylation / 2: Reduction / 3: Acylation / 4: Condensation;

DOI:10.1021/jm990967h

upstream raw materials:

3,3-dimethylbutyrylaldehyde

N-(2-fluorophenyl)benzene-1,2-diamine

Downstream raw materials:

1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

3-amino-1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine