1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Base Information

• Chemical Name: 1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine
• CAS No.: 151385-68-1
• Molecular Formula: C₂₇H₂₇FN₄O₂
• Molecular Weight: 458.535
• Mol file: 151385-68-1.mol

Synonyms:

Chemical Property of 1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

There total 3 articles about 1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3-dimethylbutyrylaldehyde (2987-16-8) → 1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine (151385-68-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / NaBH₄; CH₃COONa*3H₂O / acetic acid; H₂O; ethanol / 0.5 h / 23 °C

2: tetrahydrofuran / 3 h / 50 °C

With sodium tetrahydroborate; sodium acetate; In tetrahydrofuran; ethanol; water; acetic acid; 1: Reductive alkylation / 2: Acylation;

DOI:10.1021/jm990967h

Reference yield:

N-(2-fluorophenyl)benzene-1,2-diamine (28898-03-5) → 1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine (151385-68-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / NaBH₄; CH₃COONa*3H₂O / acetic acid; H₂O; ethanol / 0.5 h / 23 °C

2: tetrahydrofuran / 3 h / 50 °C

With sodium tetrahydroborate; sodium acetate; In tetrahydrofuran; ethanol; water; acetic acid; 1: Reductive alkylation / 2: Acylation;

DOI:10.1021/jm990967h

Reference yield:

2-(phenylhydrazono)-propanedioyl dichloride (19288-90-5) + 2-(3,3-dimethylbut-1-yl)amino-2'-fluorodiphenylamine (151385-67-0) → 1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine (151385-68-1)

Guidance literature:

In tetrahydrofuran; at 50 ℃; for 3h;

DOI:10.1021/jm990967h

upstream raw materials:

2-(phenylhydrazono)-propanedioyl dichloride

2-(3,3-dimethylbut-1-yl)amino-2'-fluorodiphenylamine

3,3-dimethylbutyrylaldehyde

N-(2-fluorophenyl)benzene-1,2-diamine

Downstream raw materials:

1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

3-amino-1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine