(S)-1,2-Dibromo-3-chloropropane

Base Information

• Chemical Name: (S)-1,2-Dibromo-3-chloropropane
• CAS No.: 145667-73-8
• Molecular Formula: C₃H₅Br₂Cl
• Molecular Weight: 236.334
• Nikkaji Number: J516.223H
• Mol file: 145667-73-8.mol

Synonyms:(S)-1,2-Dibromo-3-chloropropane;145667-73-8;CCRIS 7274;BIDD:ER0689;SCHEMBL2402865

Chemical Property of (S)-1,2-Dibromo-3-chloropropane

Chemical Property:

• Vapor Pressure: 0.503mmHg at 25°C
• Boiling Point: 198.6°C at 760 mmHg
• Flash Point: 80.5°C
• Density: 2.034g/cm³
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 2
• Exact Mass: 235.84260
• Heavy Atom Count: 6
• Complexity: 32

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(CBr)Br)Cl
• Isomeric SMILES: C([C@@H](CBr)Br)Cl

Technology Process of (S)-1,2-Dibromo-3-chloropropane

There total 9 articles about (S)-1,2-Dibromo-3-chloropropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Trifluoro-methanesulfonic acid (R)-2-bromo-1-chloromethyl-ethyl ester → (S)-(+)-1,2-dibromo-3-chloropropane (145667-73-8)

Guidance literature:

With lithium bromide; In acetonitrile; for 1h; Ambient temperature;

DOI:10.1021/jo00055a040

Reference yield: 90.0%

Trifluoro-methanesulfonic acid (S)-2-bromo-1-chloromethyl-ethyl ester → (R)-(-)-1,2-dibromo-3-chloropropane (145667-73-8)

Guidance literature:

With lithium bromide; In acetonitrile; for 1h; Ambient temperature;

DOI:10.1021/jo00055a040

Reference yield: 37.0%

3-chloroprop-1-ene (107-05-1) → nemagon (96-12-8,145667-73-8) + 1,2-difluoro-3-chloropropane (37161-81-2) + 1-bromo-3-chloro-2-fluoropropane (32753-90-5) + 2-bromo-1-chloro-3-fluoropropane (32753-89-2)

Guidance literature:

With bromine trifluoride; bromine; In 1,1,2-Trichloro-1,2,2-trifluoroethane; at 10 - 20 ℃;

upstream raw materials:

epichlorohydrin

3-chloroprop-1-ene

2,2,2-tribromo-1,3,2-benzodioxaphosphole

Downstream raw materials:

glycerol

Refernces

• 1、 -. "BROMINATED FLAME RETARDANTS AND POLYURETHANES CONTAINING THE SAME". Paragraph 0122; 0127. . Retrieved 2020/07/15.
• 2、 Kunshenko, B. V.,Mokhamed, Nagib Mukhtar,Omarov, V. O.,Muratov, N. N.,Yagupol'skii, L. M.. "REACTION OF ORGANIC COMPOUNDS WITH SF4-HF-HALOGENATING SYSTEM VII. REACTIONS OF OLEFINS WITH THE SF4-HF-Cl2(Br2) SYSTEM". . p. 511 - 518. Retrieved 2007/10/02.